Cargando…

Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey

BACKGROUND: This study aimed to investigate clinical characteristics of Korean PAP patients and to examine the potential risk factors of PAP. METHODS: We retrospectively reviewed medical records of 78 Korean PAP patients diagnosed between 1993 and 2014. Patients were classified into two groups accor...

Descripción completa

Detalles Bibliográficos
Autores principales: Hwang, Ji An, Song, Joo Han, Kim, Jung Hoon, Chung, Man Pyo, Kim, Dong Soon, Song, Jin Woo, Kim, Young Whan, Choi, Sun Mi, Cha, Seung Ick, Uh, Soo Taek, Park, Choon-Sik, Jeong, Sung Hwan, Park, Yong Bum, Lee, Hong Lyeol, Shin, Jong Wook, Lee, Eun Joo, Jegal, Yangjin, Lee, Hyun Kyung, Park, Jong Sun, Park, Moo Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697136/
https://www.ncbi.nlm.nih.gov/pubmed/29162083
http://dx.doi.org/10.1186/s12890-017-0493-4
_version_ 1783280552220033024
author Hwang, Ji An
Song, Joo Han
Kim, Jung Hoon
Chung, Man Pyo
Kim, Dong Soon
Song, Jin Woo
Kim, Young Whan
Choi, Sun Mi
Cha, Seung Ick
Uh, Soo Taek
Park, Choon-Sik
Jeong, Sung Hwan
Park, Yong Bum
Lee, Hong Lyeol
Shin, Jong Wook
Lee, Eun Joo
Jegal, Yangjin
Lee, Hyun Kyung
Park, Jong Sun
Park, Moo Suk
author_facet Hwang, Ji An
Song, Joo Han
Kim, Jung Hoon
Chung, Man Pyo
Kim, Dong Soon
Song, Jin Woo
Kim, Young Whan
Choi, Sun Mi
Cha, Seung Ick
Uh, Soo Taek
Park, Choon-Sik
Jeong, Sung Hwan
Park, Yong Bum
Lee, Hong Lyeol
Shin, Jong Wook
Lee, Eun Joo
Jegal, Yangjin
Lee, Hyun Kyung
Park, Jong Sun
Park, Moo Suk
author_sort Hwang, Ji An
collection PubMed
description BACKGROUND: This study aimed to investigate clinical characteristics of Korean PAP patients and to examine the potential risk factors of PAP. METHODS: We retrospectively reviewed medical records of 78 Korean PAP patients diagnosed between 1993 and 2014. Patients were classified into two groups according to the presence/absence of treatment (lavage). Clinical and laboratory features were compared between the two groups. RESULTS: Of the total 78 PAP patients, 60% were male and median age at diagnosis was 47.5 years. Fifty three percent were ever smokers (median 22 pack-years) and 48% had a history of dust exposure (metal 26.5%, stone or sand 20.6%, chemical or paint 17.7%, farming dust 14.7%, diesel 14.7%, textile 2.9%, and wood 2.9%). A history of cigarette smoking or dust exposure was present in 70.5% of the total PAP patients, with 23% having both of them. Patients who underwent lavage (n = 38) presented symptoms more frequently (38/38 [100%] vs. 24/40 [60%], P < 0.001) and had significantly lower PaO(2) and DL(CO) with higher D(A-a)O(2) at the onset of disease than those without lavage (n = 40) (P = 0.006, P < 0.001, and P = 0.036, respectively). Correspondingly, the distribution of disease severity score (DSS) differed significantly between the two groups (P = 0.001). Based on these, when the total patients were categorized according to DSS (low DSS [DSS 1–2] vs. high DSS [DSS 3–5]), smoking status differed significantly between the two groups with the proportion of current smokers significantly higher in the high DSS group (11/22 [50%] vs. 7/39 [17.9%], P = 0.008). Furthermore, current smokers had meaningfully higher DSS and serum CEA levels than non-current smokers (P = 0.011 and P = 0.031), whereas no difference was found between smokers and non-smokers. Regarding type of exposed dust, farming dust was significantly associated with more severe form of PAP (P = 0.004). CONCLUSION: A considerable proportion of PAP patients had a history of cigarette smoking and/or dust exposure, suggestive of their possible roles in the development of PAP. Active cigarette smoking at the onset of PAP is associated with the severity of PAP.
format Online
Article
Text
id pubmed-5697136
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-56971362017-12-01 Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey Hwang, Ji An Song, Joo Han Kim, Jung Hoon Chung, Man Pyo Kim, Dong Soon Song, Jin Woo Kim, Young Whan Choi, Sun Mi Cha, Seung Ick Uh, Soo Taek Park, Choon-Sik Jeong, Sung Hwan Park, Yong Bum Lee, Hong Lyeol Shin, Jong Wook Lee, Eun Joo Jegal, Yangjin Lee, Hyun Kyung Park, Jong Sun Park, Moo Suk BMC Pulm Med Research Article BACKGROUND: This study aimed to investigate clinical characteristics of Korean PAP patients and to examine the potential risk factors of PAP. METHODS: We retrospectively reviewed medical records of 78 Korean PAP patients diagnosed between 1993 and 2014. Patients were classified into two groups according to the presence/absence of treatment (lavage). Clinical and laboratory features were compared between the two groups. RESULTS: Of the total 78 PAP patients, 60% were male and median age at diagnosis was 47.5 years. Fifty three percent were ever smokers (median 22 pack-years) and 48% had a history of dust exposure (metal 26.5%, stone or sand 20.6%, chemical or paint 17.7%, farming dust 14.7%, diesel 14.7%, textile 2.9%, and wood 2.9%). A history of cigarette smoking or dust exposure was present in 70.5% of the total PAP patients, with 23% having both of them. Patients who underwent lavage (n = 38) presented symptoms more frequently (38/38 [100%] vs. 24/40 [60%], P < 0.001) and had significantly lower PaO(2) and DL(CO) with higher D(A-a)O(2) at the onset of disease than those without lavage (n = 40) (P = 0.006, P < 0.001, and P = 0.036, respectively). Correspondingly, the distribution of disease severity score (DSS) differed significantly between the two groups (P = 0.001). Based on these, when the total patients were categorized according to DSS (low DSS [DSS 1–2] vs. high DSS [DSS 3–5]), smoking status differed significantly between the two groups with the proportion of current smokers significantly higher in the high DSS group (11/22 [50%] vs. 7/39 [17.9%], P = 0.008). Furthermore, current smokers had meaningfully higher DSS and serum CEA levels than non-current smokers (P = 0.011 and P = 0.031), whereas no difference was found between smokers and non-smokers. Regarding type of exposed dust, farming dust was significantly associated with more severe form of PAP (P = 0.004). CONCLUSION: A considerable proportion of PAP patients had a history of cigarette smoking and/or dust exposure, suggestive of their possible roles in the development of PAP. Active cigarette smoking at the onset of PAP is associated with the severity of PAP. BioMed Central 2017-11-21 /pmc/articles/PMC5697136/ /pubmed/29162083 http://dx.doi.org/10.1186/s12890-017-0493-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Hwang, Ji An
Song, Joo Han
Kim, Jung Hoon
Chung, Man Pyo
Kim, Dong Soon
Song, Jin Woo
Kim, Young Whan
Choi, Sun Mi
Cha, Seung Ick
Uh, Soo Taek
Park, Choon-Sik
Jeong, Sung Hwan
Park, Yong Bum
Lee, Hong Lyeol
Shin, Jong Wook
Lee, Eun Joo
Jegal, Yangjin
Lee, Hyun Kyung
Park, Jong Sun
Park, Moo Suk
Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
title Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
title_full Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
title_fullStr Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
title_full_unstemmed Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
title_short Clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a Korean national survey
title_sort clinical significance of cigarette smoking and dust exposure in pulmonary alveolar proteinosis: a korean national survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697136/
https://www.ncbi.nlm.nih.gov/pubmed/29162083
http://dx.doi.org/10.1186/s12890-017-0493-4
work_keys_str_mv AT hwangjian clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT songjoohan clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT kimjunghoon clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT chungmanpyo clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT kimdongsoon clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT songjinwoo clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT kimyoungwhan clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT choisunmi clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT chaseungick clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT uhsootaek clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT parkchoonsik clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT jeongsunghwan clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT parkyongbum clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT leehonglyeol clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT shinjongwook clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT leeeunjoo clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT jegalyangjin clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT leehyunkyung clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT parkjongsun clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey
AT parkmoosuk clinicalsignificanceofcigarettesmokinganddustexposureinpulmonaryalveolarproteinosisakoreannationalsurvey