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Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog

Pseudolymphoma is a drug reaction to anti‐epileptics that is well recognized in humans; it has been reported in one cat but not dogs. In this report, lymphoma‐like clinical signs are suspected to be secondary to phenobarbital administration in a dog. A 2.5‐year‐old male, neutered Shepherd mix presen...

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Autores principales: Lampe, R., Manens, J., Sharp, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697181/
https://www.ncbi.nlm.nih.gov/pubmed/28865097
http://dx.doi.org/10.1111/jvim.14818
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author Lampe, R.
Manens, J.
Sharp, N.
author_facet Lampe, R.
Manens, J.
Sharp, N.
author_sort Lampe, R.
collection PubMed
description Pseudolymphoma is a drug reaction to anti‐epileptics that is well recognized in humans; it has been reported in one cat but not dogs. In this report, lymphoma‐like clinical signs are suspected to be secondary to phenobarbital administration in a dog. A 2.5‐year‐old male, neutered Shepherd mix presented for a 3‐day history of progressive ataxia, dazed mentation, pyrexia, and lethargy. While hospitalized, the dog developed generalized lymphadenopathy and sustained pyrexia. The dog was receiving levetiracetam and phenobarbital for epilepsy, and serum concentrations of both were within standard therapeutic ranges. Abdominal ultrasound revealed hepatomegaly, splenomegaly, and generalized lymphadenopathy. Cytology of the peripheral lymph nodes was consistent with reactive lymph nodes, and aspirates of the liver and spleen revealed histiocytic‐neutrophilic inflammation. Phenobarbital was discontinued and replaced with zonisamide. Within 24 hours, the dog was normothermic, and other clinical signs resolved within a week. This case highlights a potentially serious yet reversible adverse reaction to phenobarbital in a dog. This idiosyncratic reaction could be mistaken for neoplasia and is an important differential for lymphoma‐like signs in any dog administered phenobarbital.
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spelling pubmed-56971812017-11-29 Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog Lampe, R. Manens, J. Sharp, N. J Vet Intern Med SMALL ANIMAL Pseudolymphoma is a drug reaction to anti‐epileptics that is well recognized in humans; it has been reported in one cat but not dogs. In this report, lymphoma‐like clinical signs are suspected to be secondary to phenobarbital administration in a dog. A 2.5‐year‐old male, neutered Shepherd mix presented for a 3‐day history of progressive ataxia, dazed mentation, pyrexia, and lethargy. While hospitalized, the dog developed generalized lymphadenopathy and sustained pyrexia. The dog was receiving levetiracetam and phenobarbital for epilepsy, and serum concentrations of both were within standard therapeutic ranges. Abdominal ultrasound revealed hepatomegaly, splenomegaly, and generalized lymphadenopathy. Cytology of the peripheral lymph nodes was consistent with reactive lymph nodes, and aspirates of the liver and spleen revealed histiocytic‐neutrophilic inflammation. Phenobarbital was discontinued and replaced with zonisamide. Within 24 hours, the dog was normothermic, and other clinical signs resolved within a week. This case highlights a potentially serious yet reversible adverse reaction to phenobarbital in a dog. This idiosyncratic reaction could be mistaken for neoplasia and is an important differential for lymphoma‐like signs in any dog administered phenobarbital. John Wiley and Sons Inc. 2017-09-02 2017 /pmc/articles/PMC5697181/ /pubmed/28865097 http://dx.doi.org/10.1111/jvim.14818 Text en Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Lampe, R.
Manens, J.
Sharp, N.
Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog
title Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog
title_full Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog
title_fullStr Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog
title_full_unstemmed Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog
title_short Suspected Phenobarbital‐Induced Pseudolymphoma in a Dog
title_sort suspected phenobarbital‐induced pseudolymphoma in a dog
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697181/
https://www.ncbi.nlm.nih.gov/pubmed/28865097
http://dx.doi.org/10.1111/jvim.14818
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