Cargando…

Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart

Medicinal plants are important elements of indigenous medical system that have persisted in developing countries. Many of the botanical chemo-preventions currently used as potent anticancer agents. However, some important anticancer agents are still extracted from plants because they cannot be synth...

Descripción completa

Detalles Bibliográficos
Autores principales: Abd-Rabou, Ahmed A, Abdalla, Aboelfetoh M, Ali, Naglaa A, Zoheir, Khairy MA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697473/
https://www.ncbi.nlm.nih.gov/pubmed/28843248
http://dx.doi.org/10.22034/APJCP.2017.18.8.2141
_version_ 1783280630312730624
author Abd-Rabou, Ahmed A
Abdalla, Aboelfetoh M
Ali, Naglaa A
Zoheir, Khairy MA
author_facet Abd-Rabou, Ahmed A
Abdalla, Aboelfetoh M
Ali, Naglaa A
Zoheir, Khairy MA
author_sort Abd-Rabou, Ahmed A
collection PubMed
description Medicinal plants are important elements of indigenous medical system that have persisted in developing countries. Many of the botanical chemo-preventions currently used as potent anticancer agents. However, some important anticancer agents are still extracted from plants because they cannot be synthesized chemically on a commercial scale due to their complex structures that often contain several chiral centers. The aim of this study was to test different extracts from the Moringa oleifera leaves (ML), its PLGA-CS-PEG nanocomposites (MLn), as well as root core (Rc) and outer (Ro) parts for activity against hepatocarcinoma HepG2, breast MCF7, and colorectal HCT 116/ Caco-2 cells in vitro. Nano-composites were prepared and characterized. Then, the nanocomposites and the free counterparts were screened on different propagated cancer cell lines. The underlying cytotoxic impact was followed using apoptosis measurements. All extracts kill the different cancer cells with different ratios, but intriguingly, the root core extract could kill the majority of cancer cells (approximately 70-80%), while sparing normal BHK-21 cells with minimal inhibitory effect (approximately 30-40%). Apoptotic cell increment came to confirm the cytotoxic effects of these extracts on HCT 116 cells (Rc: 212% and Ro: 180%, respectively) and HepG2 cells (ML: 567.5% and MLn: 608%, respectively) compared to control (100%) mechanistically wise. Moringa oleifera nanocomposites may have potential for use as a natural source of anti-cancer compounds.
format Online
Article
Text
id pubmed-5697473
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher West Asia Organization for Cancer Prevention
record_format MEDLINE/PubMed
spelling pubmed-56974732017-12-01 Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart Abd-Rabou, Ahmed A Abdalla, Aboelfetoh M Ali, Naglaa A Zoheir, Khairy MA Asian Pac J Cancer Prev Research Article Medicinal plants are important elements of indigenous medical system that have persisted in developing countries. Many of the botanical chemo-preventions currently used as potent anticancer agents. However, some important anticancer agents are still extracted from plants because they cannot be synthesized chemically on a commercial scale due to their complex structures that often contain several chiral centers. The aim of this study was to test different extracts from the Moringa oleifera leaves (ML), its PLGA-CS-PEG nanocomposites (MLn), as well as root core (Rc) and outer (Ro) parts for activity against hepatocarcinoma HepG2, breast MCF7, and colorectal HCT 116/ Caco-2 cells in vitro. Nano-composites were prepared and characterized. Then, the nanocomposites and the free counterparts were screened on different propagated cancer cell lines. The underlying cytotoxic impact was followed using apoptosis measurements. All extracts kill the different cancer cells with different ratios, but intriguingly, the root core extract could kill the majority of cancer cells (approximately 70-80%), while sparing normal BHK-21 cells with minimal inhibitory effect (approximately 30-40%). Apoptotic cell increment came to confirm the cytotoxic effects of these extracts on HCT 116 cells (Rc: 212% and Ro: 180%, respectively) and HepG2 cells (ML: 567.5% and MLn: 608%, respectively) compared to control (100%) mechanistically wise. Moringa oleifera nanocomposites may have potential for use as a natural source of anti-cancer compounds. West Asia Organization for Cancer Prevention 2017 /pmc/articles/PMC5697473/ /pubmed/28843248 http://dx.doi.org/10.22034/APJCP.2017.18.8.2141 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Abd-Rabou, Ahmed A
Abdalla, Aboelfetoh M
Ali, Naglaa A
Zoheir, Khairy MA
Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
title Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
title_full Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
title_fullStr Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
title_full_unstemmed Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
title_short Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
title_sort moringa oleifera root induces cancer apoptosis more effectively than leave nanocomposites and its free counterpart
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697473/
https://www.ncbi.nlm.nih.gov/pubmed/28843248
http://dx.doi.org/10.22034/APJCP.2017.18.8.2141
work_keys_str_mv AT abdrabouahmeda moringaoleiferarootinducescancerapoptosismoreeffectivelythanleavenanocompositesanditsfreecounterpart
AT abdallaaboelfetohm moringaoleiferarootinducescancerapoptosismoreeffectivelythanleavenanocompositesanditsfreecounterpart
AT alinaglaaa moringaoleiferarootinducescancerapoptosismoreeffectivelythanleavenanocompositesanditsfreecounterpart
AT zoheirkhairyma moringaoleiferarootinducescancerapoptosismoreeffectivelythanleavenanocompositesanditsfreecounterpart