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Population Pharmacokinetics of Liposomal Irinotecan in Patients With Cancer

Nanoliposomal irinotecan (nal‐IRI) is a liposomal formulation of irinotecan with a longer half‐life (t(1/2)), higher plasma total irinotecan (tIRI), and lower SN‐38 maximum concentration (C (max)) compared with nonliposomal irinotecan. Population pharmacokinetic (PK) analysis of nal‐IRI was performe...

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Detalles Bibliográficos
Autores principales: Adiwijaya, BS, Kim, J, Lang, I, Csõszi, T, Cubillo, A, Chen, J‐S, Wong, M, Park, JO, Kim, JS, Rau, KM, Melichar, B, Gallego, JB, Fitzgerald, J, Belanger, B, Molnar, I, Ma, WW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697569/
https://www.ncbi.nlm.nih.gov/pubmed/28445610
http://dx.doi.org/10.1002/cpt.720
Descripción
Sumario:Nanoliposomal irinotecan (nal‐IRI) is a liposomal formulation of irinotecan with a longer half‐life (t(1/2)), higher plasma total irinotecan (tIRI), and lower SN‐38 maximum concentration (C (max)) compared with nonliposomal irinotecan. Population pharmacokinetic (PK) analysis of nal‐IRI was performed for tIRI and total SN‐38 (tSN38) using patient samples from six studies. PK‐safety association was evaluated for neutropenia and diarrhea in 353 patients. PK‐efficacy association was evaluated from a phase III study in pancreatic cancer NAPOLI1. Efficacy was associated with longer duration of unencapsulated SN‐38 (uSN38) above a threshold and higher C(avg) of tIRI, tSN38, and uSN38. Neutropenia was associated with uSN38 C (max) and diarrhea with tIRI C (max). Baseline predictive factors were race, body surface area, and bilirubin. Analysis identified PK factors associated with efficacy, safety, and predictive baseline factors. The results support the benefit of nal‐IRI dose of 70 mg/m(2) (free‐base; equivalent to 80 mg/m(2) salt base) Q2W over 100 mg/m(2) Q3W.