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Targeted antimicrobial therapy in the microbiome era
Even though the oral microbiome is one of the most complex sites on the body it is an excellent model for narrow‐spectrum antimicrobial therapy. Current research indicates that disruption of the microbiome leads to a dysbiotic environment allowing for the overgrowth of pathogenic species and the ons...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697594/ https://www.ncbi.nlm.nih.gov/pubmed/28609586 http://dx.doi.org/10.1111/omi.12190 |
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author | Stone, V.N. Xu, P. |
author_facet | Stone, V.N. Xu, P. |
author_sort | Stone, V.N. |
collection | PubMed |
description | Even though the oral microbiome is one of the most complex sites on the body it is an excellent model for narrow‐spectrum antimicrobial therapy. Current research indicates that disruption of the microbiome leads to a dysbiotic environment allowing for the overgrowth of pathogenic species and the onset of oral diseases. The gram‐negative colonizer, Porphyromonas gingivalis has long been considered a key player in the initiation of periodontitis and Streptococcus mutans has been linked to dental caries. With antibiotic research still on the decline, new strategies are greatly needed to combat infectious diseases. By targeting key pathogens, it may be possible to treat oral infections while allowing for the recolonization of the beneficial, healthy flora. In this review, we examine unique strategies to specifically target periodontal pathogens and address what is needed for the success of these approaches in the microbiome era. |
format | Online Article Text |
id | pubmed-5697594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56975942017-11-28 Targeted antimicrobial therapy in the microbiome era Stone, V.N. Xu, P. Mol Oral Microbiol Review Article Even though the oral microbiome is one of the most complex sites on the body it is an excellent model for narrow‐spectrum antimicrobial therapy. Current research indicates that disruption of the microbiome leads to a dysbiotic environment allowing for the overgrowth of pathogenic species and the onset of oral diseases. The gram‐negative colonizer, Porphyromonas gingivalis has long been considered a key player in the initiation of periodontitis and Streptococcus mutans has been linked to dental caries. With antibiotic research still on the decline, new strategies are greatly needed to combat infectious diseases. By targeting key pathogens, it may be possible to treat oral infections while allowing for the recolonization of the beneficial, healthy flora. In this review, we examine unique strategies to specifically target periodontal pathogens and address what is needed for the success of these approaches in the microbiome era. John Wiley and Sons Inc. 2017-08-01 2017-12 /pmc/articles/PMC5697594/ /pubmed/28609586 http://dx.doi.org/10.1111/omi.12190 Text en © 2017 The Authors. Molecular Oral Microbiology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Article Stone, V.N. Xu, P. Targeted antimicrobial therapy in the microbiome era |
title | Targeted antimicrobial therapy in the microbiome era |
title_full | Targeted antimicrobial therapy in the microbiome era |
title_fullStr | Targeted antimicrobial therapy in the microbiome era |
title_full_unstemmed | Targeted antimicrobial therapy in the microbiome era |
title_short | Targeted antimicrobial therapy in the microbiome era |
title_sort | targeted antimicrobial therapy in the microbiome era |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697594/ https://www.ncbi.nlm.nih.gov/pubmed/28609586 http://dx.doi.org/10.1111/omi.12190 |
work_keys_str_mv | AT stonevn targetedantimicrobialtherapyinthemicrobiomeera AT xup targetedantimicrobialtherapyinthemicrobiomeera |