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Selforganization of modular activity of grid cells

A unique topographical representation of space is found in the concerted activity of grid cells in the rodent medial entorhinal cortex. Many among the principal cells in this region exhibit a hexagonal firing pattern, in which each cell expresses its own set of place fields (spatial phases) at the v...

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Autores principales: Urdapilleta, Eugenio, Si, Bailu, Treves, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697658/
https://www.ncbi.nlm.nih.gov/pubmed/28768062
http://dx.doi.org/10.1002/hipo.22765
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author Urdapilleta, Eugenio
Si, Bailu
Treves, Alessandro
author_facet Urdapilleta, Eugenio
Si, Bailu
Treves, Alessandro
author_sort Urdapilleta, Eugenio
collection PubMed
description A unique topographical representation of space is found in the concerted activity of grid cells in the rodent medial entorhinal cortex. Many among the principal cells in this region exhibit a hexagonal firing pattern, in which each cell expresses its own set of place fields (spatial phases) at the vertices of a triangular grid, the spacing and orientation of which are typically shared with neighboring cells. Grid spacing, in particular, has been found to increase along the dorso‐ventral axis of the entorhinal cortex but in discrete steps, that is, with a modular structure. In this study, we show that such a modular activity may result from the self‐organization of interacting units, which individually would not show discrete but rather continuously varying grid spacing. Within our “adaptation” network model, the effect of a continuously varying time constant, which determines grid spacing in the isolated cell model, is modulated by recurrent collateral connections, which tend to produce a few subnetworks, akin to magnetic domains, each with its own grid spacing. In agreement with experimental evidence, the modular structure is tightly defined by grid spacing, but also involves grid orientation and distortion, due to interactions across modules. Thus, our study sheds light onto a possible mechanism, other than simply assuming separate networks a priori, underlying the formation of modular grid representations.
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spelling pubmed-56976582017-11-28 Selforganization of modular activity of grid cells Urdapilleta, Eugenio Si, Bailu Treves, Alessandro Hippocampus Research Articles A unique topographical representation of space is found in the concerted activity of grid cells in the rodent medial entorhinal cortex. Many among the principal cells in this region exhibit a hexagonal firing pattern, in which each cell expresses its own set of place fields (spatial phases) at the vertices of a triangular grid, the spacing and orientation of which are typically shared with neighboring cells. Grid spacing, in particular, has been found to increase along the dorso‐ventral axis of the entorhinal cortex but in discrete steps, that is, with a modular structure. In this study, we show that such a modular activity may result from the self‐organization of interacting units, which individually would not show discrete but rather continuously varying grid spacing. Within our “adaptation” network model, the effect of a continuously varying time constant, which determines grid spacing in the isolated cell model, is modulated by recurrent collateral connections, which tend to produce a few subnetworks, akin to magnetic domains, each with its own grid spacing. In agreement with experimental evidence, the modular structure is tightly defined by grid spacing, but also involves grid orientation and distortion, due to interactions across modules. Thus, our study sheds light onto a possible mechanism, other than simply assuming separate networks a priori, underlying the formation of modular grid representations. John Wiley and Sons Inc. 2017-08-14 2017-11 /pmc/articles/PMC5697658/ /pubmed/28768062 http://dx.doi.org/10.1002/hipo.22765 Text en © 2017 The Authors. Hippocampus Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Urdapilleta, Eugenio
Si, Bailu
Treves, Alessandro
Selforganization of modular activity of grid cells
title Selforganization of modular activity of grid cells
title_full Selforganization of modular activity of grid cells
title_fullStr Selforganization of modular activity of grid cells
title_full_unstemmed Selforganization of modular activity of grid cells
title_short Selforganization of modular activity of grid cells
title_sort selforganization of modular activity of grid cells
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697658/
https://www.ncbi.nlm.nih.gov/pubmed/28768062
http://dx.doi.org/10.1002/hipo.22765
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