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A mathematical function for the description of nutrient-response curve

Several mathematical equations have been proposed to modeling nutrient-response curve for animal and human justified on the goodness of fit and/or on the biological mechanism. In this paper, a functional form of a generalized quantitative model based on Rayleigh distribution principle for descriptio...

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Detalles Bibliográficos
Autor principal: Ahmadi, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697816/
https://www.ncbi.nlm.nih.gov/pubmed/29161271
http://dx.doi.org/10.1371/journal.pone.0187292
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author Ahmadi, Hamed
author_facet Ahmadi, Hamed
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description Several mathematical equations have been proposed to modeling nutrient-response curve for animal and human justified on the goodness of fit and/or on the biological mechanism. In this paper, a functional form of a generalized quantitative model based on Rayleigh distribution principle for description of nutrient-response phenomena is derived. The three parameters governing the curve a) has biological interpretation, b) may be used to calculate reliable estimates of nutrient response relationships, and c) provide the basis for deriving relationships between nutrient and physiological responses. The new function was successfully applied to fit the nutritional data obtained from 6 experiments including a wide range of nutrients and responses. An evaluation and comparison were also done based simulated data sets to check the suitability of new model and four-parameter logistic model for describing nutrient responses. This study indicates the usefulness and wide applicability of the new introduced, simple and flexible model when applied as a quantitative approach to characterizing nutrient-response curve. This new mathematical way to describe nutritional-response data, with some useful biological interpretations, has potential to be used as an alternative approach in modeling nutritional responses curve to estimate nutrient efficiency and requirements.
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spelling pubmed-56978162017-11-30 A mathematical function for the description of nutrient-response curve Ahmadi, Hamed PLoS One Research Article Several mathematical equations have been proposed to modeling nutrient-response curve for animal and human justified on the goodness of fit and/or on the biological mechanism. In this paper, a functional form of a generalized quantitative model based on Rayleigh distribution principle for description of nutrient-response phenomena is derived. The three parameters governing the curve a) has biological interpretation, b) may be used to calculate reliable estimates of nutrient response relationships, and c) provide the basis for deriving relationships between nutrient and physiological responses. The new function was successfully applied to fit the nutritional data obtained from 6 experiments including a wide range of nutrients and responses. An evaluation and comparison were also done based simulated data sets to check the suitability of new model and four-parameter logistic model for describing nutrient responses. This study indicates the usefulness and wide applicability of the new introduced, simple and flexible model when applied as a quantitative approach to characterizing nutrient-response curve. This new mathematical way to describe nutritional-response data, with some useful biological interpretations, has potential to be used as an alternative approach in modeling nutritional responses curve to estimate nutrient efficiency and requirements. Public Library of Science 2017-11-21 /pmc/articles/PMC5697816/ /pubmed/29161271 http://dx.doi.org/10.1371/journal.pone.0187292 Text en © 2017 Hamed Ahmadi http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ahmadi, Hamed
A mathematical function for the description of nutrient-response curve
title A mathematical function for the description of nutrient-response curve
title_full A mathematical function for the description of nutrient-response curve
title_fullStr A mathematical function for the description of nutrient-response curve
title_full_unstemmed A mathematical function for the description of nutrient-response curve
title_short A mathematical function for the description of nutrient-response curve
title_sort mathematical function for the description of nutrient-response curve
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697816/
https://www.ncbi.nlm.nih.gov/pubmed/29161271
http://dx.doi.org/10.1371/journal.pone.0187292
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