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Type 1 Interferons Potentiate Human CD8(+) T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway
Events defining the progression to human type 1 diabetes (T1D) have remained elusive owing to the complex interaction between genetics, the immune system, and the environment. Type 1 interferons (T1-IFN) are known to be a constituent of the autoinflammatory milieu within the pancreas of patients wit...
Autores principales: | Newby, Brittney N., Brusko, Todd M., Zou, Baiming, Atkinson, Mark A., Clare-Salzler, Michael, Mathews, Clayton E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697952/ https://www.ncbi.nlm.nih.gov/pubmed/28877912 http://dx.doi.org/10.2337/db17-0106 |
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