Increased Effector Memory Insulin-Specific CD4(+) T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes

Type 1 diabetes (T1D) results from T cell–mediated destruction of insulin-producing β-cells. Insulin represents a key self-antigen in disease pathogenesis, as recent studies identified proinsulin-responding T cells from inflamed pancreatic islets of organ donors with recent-onset T1D. These cells re...

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Detalles Bibliográficos
Autores principales: Spanier, Justin A., Sahli, Nathanael L., Wilson, Joseph C., Martinov, Tijana, Dileepan, Thamotharampillai, Burrack, Adam L., Finger, Erik B., Blazar, Bruce R., Michels, Aaron W., Moran, Antoinette, Jenkins, Marc K., Fife, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697953/
https://www.ncbi.nlm.nih.gov/pubmed/28842400
http://dx.doi.org/10.2337/db17-0666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697953/
https://www.ncbi.nlm.nih.gov/pubmed/28842400
http://dx.doi.org/10.2337/db17-0666

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