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A CRISPR screen identifies a pathway required for paraquat-induced cell death

Paraquat, a herbicide linked to Parkinson’s disease, generates reactive oxygen species (ROS) to cause cell death. Because the source of paraquat-induced ROS production remains unknown, we conducted a CRISPR-based positive selection screen to identify metabolic genes essential for paraquat-induced ce...

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Detalles Bibliográficos
Autores principales:	Reczek, Colleen R., Birsoy, Kıvanç, Kong, Hyewon, Martínez-Reyes, Inmaculada, Wang, Tim, Gao, Peng, Sabatini, David M., Chandel, Navdeep S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698099/ https://www.ncbi.nlm.nih.gov/pubmed/29058724 http://dx.doi.org/10.1038/nchembio.2499

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