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Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis

AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR). METHODS: Cholestasis was induced by bile duct ligation in 16 male Wistar rats; whereas 8 sham-operated rats were used as...

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Detalles Bibliográficos
Autores principales:	Gabbia, Daniela, Pozza, Arianna Dalla, Albertoni, Laura, Lazzari, Roberta, Zigiotto, Giorgia, Carrara, Maria, Baldo, Vincenzo, Baldovin, Tatjana, Floreani, Annarosa, Martin, Sara De
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2017
Materias:	Basic Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698245/ https://www.ncbi.nlm.nih.gov/pubmed/29204052 http://dx.doi.org/10.3748/wjg.v23.i42.7519

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