Cargando…

Pharmacokinetic, Ambulatory, and Hyperthermic Effects of 3,4-Methylenedioxy-N-Methylcathinone (Methylone) in Rats

Methylone (3,4-methylenedioxy-N-methylcathinone) is a synthetic cathinone analog of the recreational drug ecstasy. Although it is marketed to recreational users as relatively safe, fatalities due to hyperthermia, serotonin syndrome, and multi-organ system failure have been reported. Since psychophar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Štefková, Kristýna, Židková, Monika, Horsley, Rachel R., Pinterová, Nikola, Šíchová, Klára, Uttl, Libor, Balíková, Marie, Danda, Hynek, Kuchař, Martin, Páleníček, Tomáš
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698284/ https://www.ncbi.nlm.nih.gov/pubmed/29204126 http://dx.doi.org/10.3389/fpsyt.2017.00232

Ejemplares similares

Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats
por: Šíchová, Klára, et al.
Publicado: (2018)

Behavioral and Pharmacokinetic Profile of Indole-Derived Synthetic Cannabinoids JWH-073 and JWH-210 as Compared to the Phytocannabinoid Δ(9)-THC in Rats
por: Uttl, Libor, et al.
Publicado: (2018)

Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats—pharmacokinetics, effects on behaviour and thermoregulation
por: Syrová, Kateřina, et al.
Publicado: (2023)

Synthetic Aminoindanes: A Summary of Existing Knowledge
por: Pinterova, Nikola, et al.
Publicado: (2017)

Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat
por: Horsley, Rachel R., et al.
Publicado: (2018)

Methylone and Monoamine Transporters: Correlation with Toxicity
por: Sogawa, Chiharu, et al.
Publicado: (2011)

Pharmacological effects of methylone and MDMA in humans
por: Poyatos, Lourdes, et al.
Publicado: (2023)

25CN-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. elegans—Structure Determination and Synthesis of the Most Abundant Metabolites
por: Šuláková, Anna, et al.
Publicado: (2021)

Methylone and MDMA Pharmacokinetics Following Controlled Administration in Humans
por: Poyatos, Lourdes, et al.
Publicado: (2022)

Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats
por: Uttl, Libor, et al.
Publicado: (2021)

Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans
por: Di Giorgi, Alessandro, et al.
Publicado: (2023)

2C-B-Fly-NBOMe Metabolites in Rat Urine, Human Liver Microsomes and C. elegans: Confirmation with Synthesized Analytical Standards
por: Nykodemová, Jitka, et al.
Publicado: (2021)

Methylone, a rapid acting entactogen with robust anxiolytic and antidepressant-like activity
por: Warner-Schmidt, Jennifer, et al.
Publicado: (2023)

Common origin of methylenedioxy ring degradation and demethylation in bacteria
por: Takeda, Hisashi, et al.
Publicado: (2017)

Osteosarcoma Phenotype Is Inhibited by 3,4-Methylenedioxy-β-nitrostyrene
por: Messerschmitt, Patrick J., et al.
Publicado: (2012)

1-(2-Bromobenzoyl)-6,7-(methylenedioxy)isoquinoline
por: Achiwawanich, Supakit, et al.
Publicado: (2010)

Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells
por: Silva, Bárbara, et al.
Publicado: (2022)

2,3:6,7-Bis(methylenedioxy)phenanthrene
por: Wang, Yuan-Xing, et al.
Publicado: (2007)

Neurotoxicity of drugs of abuse - the case of methylenedioxy amphetamines (MDMA, ecstasy ), and amphetamines
por: Gouzoulis-Mayfrank, Euphrosyne, et al.
Publicado: (2009)

Antifungal and Antiaflatoxigenic Methylenedioxy-Containing Compounds and Piperine-Like Synthetic Compounds
por: Moon, Young-Sun, et al.
Publicado: (2016)

A Comparison of Acute Pharmacological Effects of Methylone and MDMA Administration in Humans and Oral Fluid Concentrations as Biomarkers of Exposure
por: Poyatos, Lourdes, et al.
Publicado: (2021)

Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats
por: Manke, Hayley N., et al.
Publicado: (2023)

Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis
por: Sun, Guo, et al.
Publicado: (2020)

On-surface synthesis of hydroxy-functionalized graphene nanoribbons through deprotection of methylenedioxy groups
por: Ohtomo, Manabu, et al.
Publicado: (2022)

catena-Poly[[diaquazinc(II)]-μ-4,4′-(methylenedioxy)dibenzoato]
por: Xu, Lei, et al.
Publicado: (2009)

Usefulness of Oral Fluid for Measurement of Methylone and Its Metabolites: Correlation with Plasma Drug Concentrations and the Effect of Oral Fluid pH
por: Sprega, Giorgia, et al.
Publicado: (2023)

2-Methyl-5,6-methylenedioxy-3-phenylsulfonyl-1-benzofuran
por: Choi, Hong Dae, et al.
Publicado: (2008)

3,4-Methylenedioxy methamphetamine, synthetic cathinones and psychedelics: From recreational to novel psychotherapeutic drugs
por: López-Arnau, Raúl, et al.
Publicado: (2022)

Piper nigrum CYP719A37 Catalyzes the Decisive Methylenedioxy Bridge Formation in Piperine Biosynthesis
por: Schnabel, Arianne, et al.
Publicado: (2021)

Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects in vivo
por: Wu, Guanzhao, et al.
Publicado: (2019)

2-(4-Fluorophenyl)-3-isopropylsulfinyl-5,6-methylenedioxy-1-benzofuran
por: Seo, Pil Ja, et al.
Publicado: (2011)

2-(4-Fluorophenyl)-5,6-methylenedioxy-3-methylsulfinyl-1-benzofuran
por: Choi, Hong Dae, et al.
Publicado: (2010)

3-Ethylsulfinyl-2-(4-fluorophenyl)-5,6-methylenedioxy-1-benzofuran
por: Choi, Hong Dae, et al.
Publicado: (2010)

3-Ethylsulfinyl-2-(3-fluorophenyl)-5,6-methylenedioxy-1-benzofuran
por: Choi, Hong Dae, et al.
Publicado: (2012)

Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20S)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives
por: Dai, Xiufen, et al.
Publicado: (2020)

Methylenedioxy Piperamide-Derived Compound D5 Regulates Inflammatory Cytokine Secretion in a Culture of Human Glial Cells
por: Shahbazi, Sajad, et al.
Publicado: (2022)

Hyperthermal Medication
por: De Sandfort, Barthe
Publicado: (1910)

Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis
por: Giridharan, P, et al.
Publicado: (2002)

Poly[[bis(dimethylformamide)[μ(7)-5,5′-(methylenedioxy)diisophthalato]dizinc] dimethylformamide monosolvate]
por: Li, Chuan-Qiang, et al.
Publicado: (2011)

2-(4-Fluorophenyl)-5,6-methylenedioxy-3-phenylsulfinyl-1-benzofuran monohydrate
por: Seo, Pil Ja, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_mde7phpjlv10eibm44lgd9fo58