Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination

V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows immunoglobulin heavy chain (Igh) recombination. We recently developed the DNA-based VDJ-seq assay for the unbiased quantitation...

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Detalles Bibliográficos
Autores principales: Matheson, Louise S., Bolland, Daniel J., Chovanec, Peter, Krueger, Felix, Andrews, Simon, Koohy, Hashem, Corcoran, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698286/
https://www.ncbi.nlm.nih.gov/pubmed/29204143
http://dx.doi.org/10.3389/fimmu.2017.01550

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