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Detection of Somatic Mutations in Exome Sequencing of Tumor-only Samples
Due to lack of normal samples in clinical diagnosis and to reduce costs, detection of small-scale mutations from tumor-only samples is required but remains relatively unexplored. We developed an algorithm (GATKcan) augmenting GATK with two statistics and machine learning to detect mutations in cance...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698426/ https://www.ncbi.nlm.nih.gov/pubmed/29162841 http://dx.doi.org/10.1038/s41598-017-14896-7 |