Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses

Choline acetyltransferase neurons in the vertical diagonal band of Broca (vChATs) degenerate in the early stage of Alzheimer’s disease (AD). Here, we report that vChATs directly innervate newly generated immature neurons (NGIs) in the dorsal hippocampus (dNGIs) of adult mice and regulate both the dN...

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Detalles Bibliográficos
Autores principales: Zhu, Houze, Yan, Huanhuan, Tang, Na, Li, Xinyan, Pang, Pei, Li, Hao, Chen, Wenting, Guo, Yu, Shu, Shu, Cai, You, Pei, Lei, Liu, Dan, Luo, Min-Hua, Man, Hengye, Tian, Qing, Mu, Yangling, Zhu, Ling-Qiang, Lu, Youming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698429/
https://www.ncbi.nlm.nih.gov/pubmed/29162816
http://dx.doi.org/10.1038/s41467-017-01943-0

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