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Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models

Selenoprotein P (SeP) functions as a selenium (Se)-supply protein. SeP is identified as a hepatokine, promoting insulin resistance in type 2 diabetes. Thus, the suppression of Se-supply activity of SeP might improve glucose metabolism. Here, we develop an anti-human SeP monoclonal antibody AE2 as wi...

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Detalles Bibliográficos
Autores principales:	Mita, Yuichiro, Nakayama, Kaho, Inari, Shogo, Nishito, Yukina, Yoshioka, Yuya, Sakai, Naoko, Sotani, Kanade, Nagamura, Takahiro, Kuzuhara, Yuki, Inagaki, Kumi, Iwasaki, Miki, Misu, Hirofumi, Ikegawa, Masaya, Takamura, Toshinari, Noguchi, Noriko, Saito, Yoshiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698464/ https://www.ncbi.nlm.nih.gov/pubmed/29162828 http://dx.doi.org/10.1038/s41467-017-01863-z

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