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Interleukin-6 role in head and neck squamous cell carcinoma progression
Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698512/ https://www.ncbi.nlm.nih.gov/pubmed/29204553 http://dx.doi.org/10.1016/j.wjorl.2016.05.002 |
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author | Choudhary, Moaz M. France, Thomas J. Teknos, Theodoros N. Kumar, Pawan |
author_facet | Choudhary, Moaz M. France, Thomas J. Teknos, Theodoros N. Kumar, Pawan |
author_sort | Choudhary, Moaz M. |
collection | PubMed |
description | Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways. In addition to its effects on tumor cells, IL-6 also regulates tumor progression and tumor metastasis by modulating tumor angiogenesis and tumor lymphangiogenesis. A number of studies have shown that IL-6 levels are markedly upregulated in cancer patients. We and others have shown that high IL-6 expression independently predicts tumor recurrence, tumor metastasis and poor survival in head and neck cancer patients. Therefore targeting IL-6 signaling is a potential therapeutic strategy for the treatment of head and neck squamous cell carcinoma (HNSCC). In this review, we discuss the current understanding of the role of IL-6 in HNSCC progression and potential therapeutic strategies to target IL-6 signaling for the treatment of head and neck cancer patients. |
format | Online Article Text |
id | pubmed-5698512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-56985122017-12-04 Interleukin-6 role in head and neck squamous cell carcinoma progression Choudhary, Moaz M. France, Thomas J. Teknos, Theodoros N. Kumar, Pawan World J Otorhinolaryngol Head Neck Surg Novel discoveries/Therapeutics Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways. In addition to its effects on tumor cells, IL-6 also regulates tumor progression and tumor metastasis by modulating tumor angiogenesis and tumor lymphangiogenesis. A number of studies have shown that IL-6 levels are markedly upregulated in cancer patients. We and others have shown that high IL-6 expression independently predicts tumor recurrence, tumor metastasis and poor survival in head and neck cancer patients. Therefore targeting IL-6 signaling is a potential therapeutic strategy for the treatment of head and neck squamous cell carcinoma (HNSCC). In this review, we discuss the current understanding of the role of IL-6 in HNSCC progression and potential therapeutic strategies to target IL-6 signaling for the treatment of head and neck cancer patients. KeAi Publishing 2016-07-20 /pmc/articles/PMC5698512/ /pubmed/29204553 http://dx.doi.org/10.1016/j.wjorl.2016.05.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Novel discoveries/Therapeutics Choudhary, Moaz M. France, Thomas J. Teknos, Theodoros N. Kumar, Pawan Interleukin-6 role in head and neck squamous cell carcinoma progression |
title | Interleukin-6 role in head and neck squamous cell carcinoma progression |
title_full | Interleukin-6 role in head and neck squamous cell carcinoma progression |
title_fullStr | Interleukin-6 role in head and neck squamous cell carcinoma progression |
title_full_unstemmed | Interleukin-6 role in head and neck squamous cell carcinoma progression |
title_short | Interleukin-6 role in head and neck squamous cell carcinoma progression |
title_sort | interleukin-6 role in head and neck squamous cell carcinoma progression |
topic | Novel discoveries/Therapeutics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698512/ https://www.ncbi.nlm.nih.gov/pubmed/29204553 http://dx.doi.org/10.1016/j.wjorl.2016.05.002 |
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