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Interleukin-6 role in head and neck squamous cell carcinoma progression

Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT an...

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Autores principales: Choudhary, Moaz M., France, Thomas J., Teknos, Theodoros N., Kumar, Pawan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698512/
https://www.ncbi.nlm.nih.gov/pubmed/29204553
http://dx.doi.org/10.1016/j.wjorl.2016.05.002
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author Choudhary, Moaz M.
France, Thomas J.
Teknos, Theodoros N.
Kumar, Pawan
author_facet Choudhary, Moaz M.
France, Thomas J.
Teknos, Theodoros N.
Kumar, Pawan
author_sort Choudhary, Moaz M.
collection PubMed
description Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways. In addition to its effects on tumor cells, IL-6 also regulates tumor progression and tumor metastasis by modulating tumor angiogenesis and tumor lymphangiogenesis. A number of studies have shown that IL-6 levels are markedly upregulated in cancer patients. We and others have shown that high IL-6 expression independently predicts tumor recurrence, tumor metastasis and poor survival in head and neck cancer patients. Therefore targeting IL-6 signaling is a potential therapeutic strategy for the treatment of head and neck squamous cell carcinoma (HNSCC). In this review, we discuss the current understanding of the role of IL-6 in HNSCC progression and potential therapeutic strategies to target IL-6 signaling for the treatment of head and neck cancer patients.
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spelling pubmed-56985122017-12-04 Interleukin-6 role in head and neck squamous cell carcinoma progression Choudhary, Moaz M. France, Thomas J. Teknos, Theodoros N. Kumar, Pawan World J Otorhinolaryngol Head Neck Surg Novel discoveries/Therapeutics Interleukin-6 (IL-6) is a pleiotropic cytokine which plays an important role in a number of cellular processes including proliferation, survival, differentiation, migration and invasion. IL-6 mediates its downstream effects by activating a number of signaling cascades including JAK/STAT, PI3K/AKT and MAPK pathways. In addition to its effects on tumor cells, IL-6 also regulates tumor progression and tumor metastasis by modulating tumor angiogenesis and tumor lymphangiogenesis. A number of studies have shown that IL-6 levels are markedly upregulated in cancer patients. We and others have shown that high IL-6 expression independently predicts tumor recurrence, tumor metastasis and poor survival in head and neck cancer patients. Therefore targeting IL-6 signaling is a potential therapeutic strategy for the treatment of head and neck squamous cell carcinoma (HNSCC). In this review, we discuss the current understanding of the role of IL-6 in HNSCC progression and potential therapeutic strategies to target IL-6 signaling for the treatment of head and neck cancer patients. KeAi Publishing 2016-07-20 /pmc/articles/PMC5698512/ /pubmed/29204553 http://dx.doi.org/10.1016/j.wjorl.2016.05.002 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Novel discoveries/Therapeutics
Choudhary, Moaz M.
France, Thomas J.
Teknos, Theodoros N.
Kumar, Pawan
Interleukin-6 role in head and neck squamous cell carcinoma progression
title Interleukin-6 role in head and neck squamous cell carcinoma progression
title_full Interleukin-6 role in head and neck squamous cell carcinoma progression
title_fullStr Interleukin-6 role in head and neck squamous cell carcinoma progression
title_full_unstemmed Interleukin-6 role in head and neck squamous cell carcinoma progression
title_short Interleukin-6 role in head and neck squamous cell carcinoma progression
title_sort interleukin-6 role in head and neck squamous cell carcinoma progression
topic Novel discoveries/Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698512/
https://www.ncbi.nlm.nih.gov/pubmed/29204553
http://dx.doi.org/10.1016/j.wjorl.2016.05.002
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