Cargando…

UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by the enzy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Liang, Salas, Omar, Bowler, Kyle, Bar-Peled, Maor, Sharon, Amir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698552/ https://www.ncbi.nlm.nih.gov/pubmed/29162710 http://dx.doi.org/10.1128/mBio.01559-17

Ejemplares similares

Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors
por: Martin del Campo, Julia S., et al.
Publicado: (2017)

Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens
por: Kizjakina, Karina, et al.
Publicado: (2013)

In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction
por: Mehra-Chaudhary, Ritcha, et al.
Publicado: (2016)

Author Correction: Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors
por: Martin del Campo, Julia S., et al.
Publicado: (2018)

QM/MM Molecular Dynamics Study of the Galactopyranose → Galactofuranose Reaction Catalysed by Trypanosoma cruzi UDP-Galactopyranose Mutase
por: Pierdominici-Sottile, Gustavo, et al.
Publicado: (2014)

Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence Factor UDP-Galactopyranose Mutase
por: Qi, Jun, et al.
Publicado: (2011)

Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus
por: Penman, George A., et al.
Publicado: (2012)

Biosynthesis of UDP-xylose and UDP-arabinose in Sinorhizobium meliloti 1021: first characterization of a bacterial UDP-xylose synthase, and UDP-xylose 4-epimerase
por: Gu, Xiaogang, et al.
Publicado: (2011)

Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics
por: Da Fonseca, Isabel, et al.
Publicado: (2014)

Cynaroside inhibits Leishmania donovani UDP-galactopyranose mutase and induces reactive oxygen species to exert antileishmanial response
por: Tabrez, Shams, et al.
Publicado: (2021)

Aspergillus nidulans Cell Wall Composition and Function Change in Response to Hosting Several Aspergillus fumigatus UDP-Galactopyranose Mutase Activity Mutants
por: Alam, Md Kausar, et al.
Publicado: (2014)

Chemical Mechanism of UDP-Galactopyranose Mutase from Trypanosoma cruzi: A Potential Drug Target against Chagas' Disease
por: Oppenheimer, Michelle, et al.
Publicado: (2012)

Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus
por: van Straaten, Karin E., et al.
Publicado: (2012)

Pyrazole and Triazole Derivatives as Mycobacterium tuberculosis UDP-Galactopyranose Inhibitors
por: Ahmed, Dalia M., et al.
Publicado: (2022)

Molecular characteristics of plant UDP-arabinopyranose mutases
por: Saqib, Anam, et al.
Publicado: (2019)

RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae
por: Misra, Sweta, et al.
Publicado: (2017)

The Biosynthesis of UDP-d-QuiNAc in Bacillus cereus ATCC 14579
por: Hwang, Soyoun, et al.
Publicado: (2015)

Synthesis of UDP-apiose in Bacteria: The marine phototroph Geminicoccus roseus and the plant pathogen Xanthomonas pisi
por: Smith, James Amor, et al.
Publicado: (2017)

Cell wall composition and digestibility alterations in Brachypodium distachyon achieved through reduced expression of the UDP-arabinopyranose mutase
por: Rancour, David M., et al.
Publicado: (2015)

UDP-xylose and UDP-galactose synthesis in Trichomonas vaginalis
por: Rosenberger, Andrea F.N., et al.
Publicado: (2012)

Facile and Stereo-Selective Synthesis of UDP-α-D-xylose and UDP-β-L-arabinose Using UDP-Sugar Pyrophosphorylase
por: Wang, JiaJia, et al.
Publicado: (2018)

Identification of UDP-rhamnosyltransferases and UDP-galactosyltransferase involved in flavonol glycosylation in Morella rubra
por: Ren, Chuanhong, et al.
Publicado: (2022)

UDP-Galactose 4′-Epimerase Activities toward UDP-Gal and UDP-GalNAc Play Different Roles in the Development of Drosophila melanogaster
por: Daenzer, Jennifer M. I., et al.
Publicado: (2012)

Arabidopsis MAP-Kinase 3 Phosphorylates UDP-Glucose Dehydrogenase: a Key Enzyme Providing UDP-Sugar for Cell Wall Biosynthesis
por: Kohlberger, Michael, et al.
Publicado: (2018)

Enzymatic C4‐Epimerization of UDP‐Glucuronic Acid: Precisely Steered Rotation of a Transient 4‐Keto Intermediate for an Inverted Reaction without Decarboxylation
por: Borg, Annika J. E., et al.
Publicado: (2022)

UDP calzado, Acatlán, Veracruz
por: Ramírez Vázquez, Cindy Berenice
Publicado: (2014)

Downregulation of a UDP-Arabinomutase Gene in Switchgrass (Panicum virgatum L.) Results in Increased Cell Wall Lignin While Reducing Arabinose-Glycans
por: Willis, Jonathan D., et al.
Publicado: (2016)

Determination of UDP-Glucose and UDP-Galactose in Maize by Hydrophilic Interaction Liquid Chromatography and Tandem Mass Spectrometry
por: Lan, Chen, et al.
Publicado: (2022)

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target
por: Fang, Wenxia, et al.
Publicado: (2013)

UDP-sulfoquinovose formation by Sulfolobus acidocaldarius
por: Zolghadr, Behnam, et al.
Publicado: (2015)

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major
por: Damerow, Sebastian, et al.
Publicado: (2015)

Three UDP-xylose transporters participate in xylan biosynthesis by conveying cytosolic UDP-xylose into the Golgi lumen in Arabidopsis
por: Zhao, Xianhai, et al.
Publicado: (2018)

New steps in mucilage biosynthesis revealed by analysis of the transcriptome of the UDP-rhamnose/UDP-galactose transporter 2 mutant
por: Parra-Rojas, Juan Pablo, et al.
Publicado: (2019)

Correction: Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major
por: Damerow, Sebastian, et al.
Publicado: (2016)

The UDP-glucosyltransferase multigene family in Bombyx mori
por: Huang, Fei-Fei, et al.
Publicado: (2008)

Cloning, Expression and Characterization of UDP-Glucose Dehydrogenases
por: Couto, Márcia R., et al.
Publicado: (2021)

UDP-glucose, cereblon-dependent proinsulin degrader
por: Cho, Jaeyong, et al.
Publicado: (2022)

Structure-function and engineering of plant UDP-glycosyltransferase
por: Wang, Mengya, et al.
Publicado: (2023)

Isotope Probing of the UDP‐Apiose/UDP‐Xylose Synthase Reaction: Evidence of a Mechanism via a Coupled Oxidation and Aldol Cleavage
por: Eixelsberger, Thomas, et al.
Publicado: (2017)

Immobilization of the Highly Active UDP-Glucose Pyrophosphorylase From Thermocrispum agreste Provides a Highly Efficient Biocatalyst for the Production of UDP-Glucose
por: Kumpf, Antje, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_goonsstqfk9afcrc5umjsufbc8