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UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by the enzy...

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Detalles Bibliográficos
Autores principales:	Ma, Liang, Salas, Omar, Bowler, Kyle, Bar-Peled, Maor, Sharon, Amir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698552/ https://www.ncbi.nlm.nih.gov/pubmed/29162710 http://dx.doi.org/10.1128/mBio.01559-17

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