Cargando…

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals. Coronavirus RNA synthesis is thought to be associated with replication organelles (ROs) consisting of modified endoplasmic reticulu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oudshoorn, Diede, Rijs, Kevin, Limpens, Ronald W. A. L., Groen, Kevin, Koster, Abraham J., Snijder, Eric J., Kikkert, Marjolein, Bárcena, Montserrat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698553/ https://www.ncbi.nlm.nih.gov/pubmed/29162711 http://dx.doi.org/10.1128/mBio.01658-17

Ejemplares similares

Biogenesis and architecture of arterivirus replication organelles
por: van der Hoeven, Barbara, et al.
Publicado: (2016)

Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus
por: Oudshoorn, Diede, et al.
Publicado: (2016)

Arterivirus nsp2 Cysteine Proteinase
por: Kikkert, Marjolein, et al.
Publicado: (2013)

Arterivirus nsp12 versus the coronavirus nsp16 2′-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins
por: Lehmann, Kathleen C., et al.
Publicado: (2015)

Regulation of the innate immune system by ubiquitin and ubiquitin-like modifiers
por: Oudshoorn, Diede, et al.
Publicado: (2012)

Coronaviral Main Protease Induces LPCAT3 Cleavage and Endoplasmic Reticulum (ER) Stress
por: Wang, Jia, et al.
Publicado: (2023)

Rotaviral and Coronaviral Diarrhea
por: Torres-Medina, Alfonso, et al.
Publicado: (1985)

A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein
por: Littler, Dene R., et al.
Publicado: (2021)

Polyprotein cleavage mechanism of SARS CoV M(pro) and chemical modification of the octapeptide
por: Du, Qi-Shi, et al.
Publicado: (2004)

Insights into the Dynamics and Binding of Two Polyprotein Substrate Cleavage Points in the Context of the SARS-CoV-2 Main and Papain-like Proteases
por: Sanusi, Zainab Kemi, et al.
Publicado: (2022)

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment
por: de Wilde, Adriaan H., et al.
Publicado: (2013)

Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis
por: Pène, Véronique, et al.
Publicado: (2017)

SARS-CoV-2 polyprotein substrate regulates the stepwise M(pro) cleavage reaction
por: Narwal, Manju, et al.
Publicado: (2023)

Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication
por: Pierce, Danielle M., et al.
Publicado: (2023)

Ferret Systemic Coronaviral Disease (FSCD)
Publicado: (2013)

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
por: Ogando, Natacha S., et al.
Publicado: (2020)

Identification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element
por: George, Maja, et al.
Publicado: (2011)

Inhibition of 2A-mediated ‘cleavage’ of certain artificial polyproteins bearing N-terminal signal sequences
por: de Felipe, Pablo, et al.
Publicado: (2010)

Regulation of coronavirus nsp15 cleavage specificity by RNA structure
por: Salukhe, Indraneel, et al.
Publicado: (2023)

Polyproteins in structural biology
por: Crépin, Thibaut, et al.
Publicado: (2015)

Host proteases as determinants of coronaviral neurotropism and virulence
por: Vavougios, George D.
Publicado: (2020)

Lithium and coronaviral infections. A scoping review.
por: Nowak, Jan K., et al.
Publicado: (2020)

Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Hamilton, M.C.K., et al.
Publicado: (2020)

Neuroimmune multi-hit perspective of coronaviral infection
por: Hayley, Shawn, et al.
Publicado: (2021)

Coronaviral RNA-methyltransferases: function, structure and inhibition
por: Nencka, Radim, et al.
Publicado: (2022)

The Transformation of Enterovirus Replication Structures: a Three-Dimensional Study of Single- and Double-Membrane Compartments
por: Limpens, Ronald W. A. L., et al.
Publicado: (2011)

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
por: Rausalu, Kai, et al.
Publicado: (2016)

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage
por: Huang, Cheng, et al.
Publicado: (2011)

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2
por: Zhao, Yao, et al.
Publicado: (2022)

Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
por: Scott, Benjamin M., et al.
Publicado: (2022)

Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity
por: Yang, Cheng-Wei, et al.
Publicado: (2017)

COVID-19 and coronaviral hepatitis: evidence of collateral damage
por: Parvez, Mohammad K
Publicado: (2020)

Re: Controversy in coronaViral Imaging and Diagnostics (COVID)
por: Morozov, S., et al.
Publicado: (2020)

Feline Infectious Peritonitis: An Immune-Mediated Coronaviral Vasculitis
por: August, John R.
Publicado: (1984)

Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents
por: Godinho, Patrícia I. C., et al.
Publicado: (2021)

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics
por: Kaul, Artur, et al.
Publicado: (2009)

Identification of Cleavage Sites Recognized by the 3C-Like Cysteine Protease within the Two Polyproteins of Strawberry Mottle Virus
por: Mann, Krin S., et al.
Publicado: (2017)

Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus
por: Wahaab, Abdul, et al.
Publicado: (2021)

Exploring cleavage activity of NSP15 using single molecule PIE-FRET
por: Gordon, Kenya, et al.
Publicado: (2023)

Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug
por: Srikanth, Lokanathan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7iqb2j47512hf51iabhsoqbrfl