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Risk factors for thiopurine‐induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype

BACKGROUND: Leucopenia is a common side effect in patients treated with thiopurines. Variants in the thiopurine S‐methyltransferase (TPMT) gene are the best‐known risk factor, but only explain up to 25% of leucopenia cases. AIM: To identify the clinical risk factors for thiopurine‐induced leucopenia...

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Detalles Bibliográficos
Autores principales:	Broekman, M. M. T. J., Coenen, M. J. H., Wanten, G. J., van Marrewijk, C. J., Klungel, O. H., Verbeek, A. L. M., Hooymans, P. M., Guchelaar, H.‐J., Scheffer, H., Derijks, L. J. J., Wong, D. R., de Jong, D. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Thiopurine Myelosuppression and Infections in IBD
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698717/ https://www.ncbi.nlm.nih.gov/pubmed/28914446 http://dx.doi.org/10.1111/apt.14323

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