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Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model
Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698784/ https://www.ncbi.nlm.nih.gov/pubmed/29250546 http://dx.doi.org/10.1155/2017/6302869 |
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author | Ross, Gloria Romina Fabersani, Emanuel Russo, Matías Gómez, Alba Japaze, Hugo González, Silvia Nelina Gauffin Cano, Paola |
author_facet | Ross, Gloria Romina Fabersani, Emanuel Russo, Matías Gómez, Alba Japaze, Hugo González, Silvia Nelina Gauffin Cano, Paola |
author_sort | Ross, Gloria Romina |
collection | PubMed |
description | Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended. |
format | Online Article Text |
id | pubmed-5698784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56987842017-12-17 Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model Ross, Gloria Romina Fabersani, Emanuel Russo, Matías Gómez, Alba Japaze, Hugo González, Silvia Nelina Gauffin Cano, Paola Biomed Res Int Research Article Iodine is an important micronutrient required for nutrition. Excess iodine has adverse effects on thyroid, but there is not enough information regarding its effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide, so its intake could be excessive during pregnancy, lactation, and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation, and postweaning period in mouse. During assay, mice were allocated into groups: control and treatment groups (received distilled water with NaI 1 mg/mL). Water intake, glandular weight, and histology were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than control groups. Lymphocyte infiltration was observed in animals of treatment groups, while there was no infiltration in glandular sections of control groups. Results demonstrated that a negative relationship could exist between iodide excess and salivary glands. This work is novel evidence that high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be considered, especially in pregnant/lactating women, to whom a higher iodine intake is usually recommended. Hindawi 2017 2017-11-08 /pmc/articles/PMC5698784/ /pubmed/29250546 http://dx.doi.org/10.1155/2017/6302869 Text en Copyright © 2017 Gloria Romina Ross et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ross, Gloria Romina Fabersani, Emanuel Russo, Matías Gómez, Alba Japaze, Hugo González, Silvia Nelina Gauffin Cano, Paola Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model |
title | Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model |
title_full | Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model |
title_fullStr | Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model |
title_full_unstemmed | Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model |
title_short | Effect of Excess Iodide Intake on Salivary Glands in a Swiss Albino Mice Model |
title_sort | effect of excess iodide intake on salivary glands in a swiss albino mice model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698784/ https://www.ncbi.nlm.nih.gov/pubmed/29250546 http://dx.doi.org/10.1155/2017/6302869 |
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