Cargando…

Exome Sequencing of Extended Families with Alzheimer’s Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function

OBJECTIVE: Alzheimer’s disease (AD) is a neurodegenerative disorder for which more than 20 genetic loci have been implicated to date. However, studies demonstrate not all genetic factors have been identified. Therefore, in this study we seek to identify additional rare variants and novel genes poten...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cukier, HN, Kunkle, BK, Hamilton, KL, Rolati, S, Kohli, MA, Whitehead, PL, Jaworski, J, Vance, JM, Cuccaro, ML, Carney, RM, Gilbert, JR, Farrer, LA, Martin, ER, Beecham, GW, Haines, JL, Pericak-Vance, MA
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698805/ https://www.ncbi.nlm.nih.gov/pubmed/29177109 http://dx.doi.org/10.4172/2161-0460.1000355

Ejemplares similares

Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease
por: Kohli, Martin A., et al.
Publicado: (2016)

ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
por: Cukier, Holly N., et al.
Publicado: (2016)

SORL1 mutations in early- and late-onset Alzheimer disease
por: Cuccaro, Michael L., et al.
Publicado: (2016)

Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders
por: Cukier, Holly N, et al.
Publicado: (2014)

Use of local genetic ancestry to assess TOMM40-523′ and risk for Alzheimer disease
por: Bussies, Parker L., et al.
Publicado: (2020)

A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism
por: Hussman, John P, et al.
Publicado: (2011)

Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease
por: Zhang, Xiaoling, et al.
Publicado: (2021)

Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci
por: Hedges, Dale J, et al.
Publicado: (2012)

Copy Number Variants in Extended Autism Spectrum Disorder Families Reveal Candidates Potentially Involved in Autism Risk
por: Salyakina, Daria, et al.
Publicado: (2011)

Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population
por: Godrich, Dana, et al.
Publicado: (2022)

GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis
por: Hussman, J P, et al.
Publicado: (2016)

Whole exome sequencing of extreme age-related macular degeneration phenotypes
por: Sardell, Rebecca J., et al.
Publicado: (2016)

Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
por: Collins, Ann L., et al.
Publicado: (2006)

FE65 Binds Teashirt, Inhibiting Expression of the Primate-Specific Caspase-4
por: Kajiwara, Yuji, et al.
Publicado: (2009)

An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
por: Chung, Ren-Hua, et al.
Publicado: (2011)

C9ORF72 Intermediate Repeat Copies Are a Significant Risk Factor for Parkinson Disease
por: Nuytemans, Karen, et al.
Publicado: (2013)

The Impact of the Human Genome Project on Complex Disease
por: Cooke Bailey, Jessica N., et al.
Publicado: (2014)

Exome Sequencing of a Multigenerational Human Pedigree
por: Hedges, Dale, et al.
Publicado: (2009)

One for all and all for One: Improving replication of genetic studies through network diffusion
por: Lancour, Daniel, et al.
Publicado: (2018)

Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease
por: Lancour, Daniel, et al.
Publicado: (2020)

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
por: Rajabli, Farid, et al.
Publicado: (2018)

Correction: Exome Sequencing of a Multigenerational Human Pedigree
por: Hedges, Dale J., et al.
Publicado: (2009)

Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons
por: DeRosa, Brooke A., et al.
Publicado: (2018)

Author Correction: Convergent Pathways in Idiopathic Autism Revealed by Time Course Transcriptomic Analysis of Patient-Derived Neurons
por: DeRosa, Brooke A., et al.
Publicado: (2022)

DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient
por: Wang, Liyong, et al.
Publicado: (2016)

Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients
por: Liu, Zhi, et al.
Publicado: (2017)

Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease
por: Beecham, Gary W., et al.
Publicado: (2018)

Targeted massively parallel sequencing of autism spectrum disorder-associated genes in a case control cohort reveals rare loss-of-function risk variants
por: Griswold, Anthony J., et al.
Publicado: (2015)

CpG‐related SNPs in the MS4A region have a dose‐dependent effect on risk of late–onset Alzheimer disease
por: Ma, Yiyi, et al.
Publicado: (2019)

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities
por: Naj, Adam C., et al.
Publicado: (2010)

A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer’s Disease in African Ancestry
por: Rajabli, Farid, et al.
Publicado: (2022)

UTILITY OF BLOOD PRESSURE GENETIC RISK SCORE IN ADMIXED HISPANIC SAMPLES
por: Beecham, Ashley H., et al.
Publicado: (2016)

Regional Differential Genetic Response of Human Articular Cartilage to Impact Injury
por: Vernon, Lauren L., et al.
Publicado: (2015)

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
por: Chung, Jaeyoon, et al.
Publicado: (2018)

Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease
por: Xue, Diane, et al.
Publicado: (2021)

The Alzheimer's Disease Sequencing Project: Study design and sample selection
por: Beecham, Gary W., et al.
Publicado: (2017)

Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish
por: McCauley, Jacob L, et al.
Publicado: (2006)

Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach
por: Edwards, Yvonne J. K., et al.
Publicado: (2011)

Plasma Metabolomics of Intermediate and Neovascular Age-Related Macular Degeneration Patients
por: Mitchell, Sabrina L., et al.
Publicado: (2021)

Whole genome sequencing of Caribbean Hispanic families with late‐onset Alzheimer's disease
por: Vardarajan, Badri N., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_un1b0otdtg9ooocgrbktqgml5s