High‐Performance Liquid Chromatography Method for Rich Pharmacokinetic Sampling Schemes in Translational Rat Toxicity Models With Vancomycin

A translational need exists to understand and predict vancomycin‐induced kidney toxicity. We describe: (i) a vancomycin high‐performance liquid chromatography (HPLC) method for rat plasma and kidney tissue homogenate; (ii) a rat pharmacokinetic (PK) study to demonstrate utility; and (iii) a catheter...

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Detalles Bibliográficos
Autores principales: Joshi, MD, O'Donnell, JN, Venkatesan, N, Chang, J, Nguyen, H, Rhodes, NJ, Pais, G, Chapman, RL, Griffin, B, Scheetz, MH
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698807/
https://www.ncbi.nlm.nih.gov/pubmed/28675684
http://dx.doi.org/10.1111/cts.12484

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