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Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study

INTRODUCTION: Adverse drug interaction is a major cause of morbidity and mortality. Its occurrence is influenced by a multitude of factors. The influences of drug-drug interactions (DDIs) can be minimized through creation of awareness to health care professionals. OBJECTIVE: The objective of this st...

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Autores principales: Gebretsadik, Zeru, Gebrehans, Micheale, Getnet, Desalegn, Gebrie, Desye, Alema, Tsgab, Belay, Yared Belete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698828/
https://www.ncbi.nlm.nih.gov/pubmed/29250554
http://dx.doi.org/10.1155/2017/9792363
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author Gebretsadik, Zeru
Gebrehans, Micheale
Getnet, Desalegn
Gebrie, Desye
Alema, Tsgab
Belay, Yared Belete
author_facet Gebretsadik, Zeru
Gebrehans, Micheale
Getnet, Desalegn
Gebrie, Desye
Alema, Tsgab
Belay, Yared Belete
author_sort Gebretsadik, Zeru
collection PubMed
description INTRODUCTION: Adverse drug interaction is a major cause of morbidity and mortality. Its occurrence is influenced by a multitude of factors. The influences of drug-drug interactions (DDIs) can be minimized through creation of awareness to health care professionals. OBJECTIVE: The objective of this study was to assess DDIs in Ayder Comprehensive Specialized Hospital (ACSH). METHODOLOGY: A retrospective study design was employed on patient prescriptions available in the outpatient department of pharmacy and filled from September 2016 to February 2017 in ACSH. RESULT: From the 600 prescription records assessed, the average number of drugs on single prescription was 2.73. Regarding the interaction observed 34 (9.63%) prescriptions with major drug-drug interaction, 210 (59.5%) moderate, 87 (24.65%) minor, and 22 (6.22%) unknown were identified. Age category showed significant association to affect the occurrence of DDIs and polypharmacy had statistically significant association with DDIs in bivariate analysis which was lost in adjusted OR. CONCLUSION: From the current study it can be concluded that nearly half of the prescription ordered in ACSH contained DDIs and from the prescription with interacting medications majority of them had moderate DDIs.
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spelling pubmed-56988282017-12-17 Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study Gebretsadik, Zeru Gebrehans, Micheale Getnet, Desalegn Gebrie, Desye Alema, Tsgab Belay, Yared Belete Biomed Res Int Research Article INTRODUCTION: Adverse drug interaction is a major cause of morbidity and mortality. Its occurrence is influenced by a multitude of factors. The influences of drug-drug interactions (DDIs) can be minimized through creation of awareness to health care professionals. OBJECTIVE: The objective of this study was to assess DDIs in Ayder Comprehensive Specialized Hospital (ACSH). METHODOLOGY: A retrospective study design was employed on patient prescriptions available in the outpatient department of pharmacy and filled from September 2016 to February 2017 in ACSH. RESULT: From the 600 prescription records assessed, the average number of drugs on single prescription was 2.73. Regarding the interaction observed 34 (9.63%) prescriptions with major drug-drug interaction, 210 (59.5%) moderate, 87 (24.65%) minor, and 22 (6.22%) unknown were identified. Age category showed significant association to affect the occurrence of DDIs and polypharmacy had statistically significant association with DDIs in bivariate analysis which was lost in adjusted OR. CONCLUSION: From the current study it can be concluded that nearly half of the prescription ordered in ACSH contained DDIs and from the prescription with interacting medications majority of them had moderate DDIs. Hindawi 2017 2017-11-08 /pmc/articles/PMC5698828/ /pubmed/29250554 http://dx.doi.org/10.1155/2017/9792363 Text en Copyright © 2017 Zeru Gebretsadik et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gebretsadik, Zeru
Gebrehans, Micheale
Getnet, Desalegn
Gebrie, Desye
Alema, Tsgab
Belay, Yared Belete
Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study
title Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study
title_full Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study
title_fullStr Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study
title_full_unstemmed Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study
title_short Assessment of Drug-Drug Interaction in Ayder Comprehensive Specialized Hospital, Mekelle, Northern Ethiopia: A Retrospective Study
title_sort assessment of drug-drug interaction in ayder comprehensive specialized hospital, mekelle, northern ethiopia: a retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698828/
https://www.ncbi.nlm.nih.gov/pubmed/29250554
http://dx.doi.org/10.1155/2017/9792363
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