Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings

[Image: see text] An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for th...

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Detalles Bibliográficos
Autores principales: Abdelraheem, Eman M. M., Madhavachary, Rudrakshula, Rossetti, Arianna, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Shaabani, Shabnam, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698880/
https://www.ncbi.nlm.nih.gov/pubmed/29083197
http://dx.doi.org/10.1021/acs.orglett.7b03094
Descripción
Sumario:[Image: see text] An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8–11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad substrate scope.

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