Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings

[Image: see text] An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for th...

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Autores principales: Abdelraheem, Eman M. M., Madhavachary, Rudrakshula, Rossetti, Arianna, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Shaabani, Shabnam, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698880/
https://www.ncbi.nlm.nih.gov/pubmed/29083197
http://dx.doi.org/10.1021/acs.orglett.7b03094
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author Abdelraheem, Eman M. M.
Madhavachary, Rudrakshula
Rossetti, Arianna
Kurpiewska, Katarzyna
Kalinowska-Tłuścik, Justyna
Shaabani, Shabnam
Dömling, Alexander
author_facet Abdelraheem, Eman M. M.
Madhavachary, Rudrakshula
Rossetti, Arianna
Kurpiewska, Katarzyna
Kalinowska-Tłuścik, Justyna
Shaabani, Shabnam
Dömling, Alexander
author_sort Abdelraheem, Eman M. M.
collection PubMed
description [Image: see text] An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8–11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad substrate scope.
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spelling pubmed-56988802017-11-27 Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings Abdelraheem, Eman M. M. Madhavachary, Rudrakshula Rossetti, Arianna Kurpiewska, Katarzyna Kalinowska-Tłuścik, Justyna Shaabani, Shabnam Dömling, Alexander Org Lett [Image: see text] An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as the starting material for the second phase. The Ugi-4-center 3-component reaction was utilized to construct complex medium-sized rings (8–11) by the addition of isocyanides and oxo components. This method features mild conditions and a broad substrate scope. American Chemical Society 2017-10-30 2017-11-17 /pmc/articles/PMC5698880/ /pubmed/29083197 http://dx.doi.org/10.1021/acs.orglett.7b03094 Text en Copyright © 2017 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Abdelraheem, Eman M. M.
Madhavachary, Rudrakshula
Rossetti, Arianna
Kurpiewska, Katarzyna
Kalinowska-Tłuścik, Justyna
Shaabani, Shabnam
Dömling, Alexander
Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
title Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
title_full Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
title_fullStr Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
title_full_unstemmed Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
title_short Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings
title_sort ugi multicomponent reaction based synthesis of medium-sized rings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698880/
https://www.ncbi.nlm.nih.gov/pubmed/29083197
http://dx.doi.org/10.1021/acs.orglett.7b03094
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