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New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec.
The first investigation of the chemical constituents and bioactivities of Diospyros rubra Lec. is reported. D. rubra extracts were screened for antimicrobial, antimalarial and cytotoxic activities. They were only shown to be active antimalarials. The extracts with good antimalarial activity were iso...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698898/ https://www.ncbi.nlm.nih.gov/pubmed/29255382 |
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author | Prachayasittikul, Supaluk Saraban, Puttirat Cherdtrakulkiat, Rungrot Ruchirawat, Somsak Prachayasittikul, Virapong |
author_facet | Prachayasittikul, Supaluk Saraban, Puttirat Cherdtrakulkiat, Rungrot Ruchirawat, Somsak Prachayasittikul, Virapong |
author_sort | Prachayasittikul, Supaluk |
collection | PubMed |
description | The first investigation of the chemical constituents and bioactivities of Diospyros rubra Lec. is reported. D. rubra extracts were screened for antimicrobial, antimalarial and cytotoxic activities. They were only shown to be active antimalarials. The extracts with good antimalarial activity were isolated and extensively purified to give lupeol (1), lupenone (2), betulin (3), lupeol acetate (4), 28-O-acetylbetulin (5), β-sitosteryl-3-O-β-D-glucopyranoside (6) and a mixture of β-sitosterol and stigmasterol. Some of the isolates were tested for antimicrobial and cytotoxic actions. Betulin (3) displayed antimicrobial activity against Streptococcus pyogenes with a minimum inhibitory concentration (MIC) of 85 μg/mL. Interestingly, bioactive fractions all selectively exerted some antimicrobial activity against Corynebacterium diphtheriae NCTC 10356 with the MIC range of 64-256 μg/mL. The study provides data to support the medicinal importance of the D. rubra. |
format | Online Article Text |
id | pubmed-5698898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-56988982017-12-18 New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. Prachayasittikul, Supaluk Saraban, Puttirat Cherdtrakulkiat, Rungrot Ruchirawat, Somsak Prachayasittikul, Virapong EXCLI J Original Article The first investigation of the chemical constituents and bioactivities of Diospyros rubra Lec. is reported. D. rubra extracts were screened for antimicrobial, antimalarial and cytotoxic activities. They were only shown to be active antimalarials. The extracts with good antimalarial activity were isolated and extensively purified to give lupeol (1), lupenone (2), betulin (3), lupeol acetate (4), 28-O-acetylbetulin (5), β-sitosteryl-3-O-β-D-glucopyranoside (6) and a mixture of β-sitosterol and stigmasterol. Some of the isolates were tested for antimicrobial and cytotoxic actions. Betulin (3) displayed antimicrobial activity against Streptococcus pyogenes with a minimum inhibitory concentration (MIC) of 85 μg/mL. Interestingly, bioactive fractions all selectively exerted some antimicrobial activity against Corynebacterium diphtheriae NCTC 10356 with the MIC range of 64-256 μg/mL. The study provides data to support the medicinal importance of the D. rubra. Leibniz Research Centre for Working Environment and Human Factors 2010-01-15 /pmc/articles/PMC5698898/ /pubmed/29255382 Text en Copyright © 2010 Prachayasittikul et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Original Article Prachayasittikul, Supaluk Saraban, Puttirat Cherdtrakulkiat, Rungrot Ruchirawat, Somsak Prachayasittikul, Virapong New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. |
title | New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. |
title_full | New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. |
title_fullStr | New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. |
title_full_unstemmed | New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. |
title_short | New bioactive triterpenoids and antimalarial activity of Diospyros rubra Lec. |
title_sort | new bioactive triterpenoids and antimalarial activity of diospyros rubra lec. |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698898/ https://www.ncbi.nlm.nih.gov/pubmed/29255382 |
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