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Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant
Macrophage activation syndrome (MAS) is a potentially fatal complication caused by excessive activation and expansion of macrophages and T lymphocytes. It can be triggered by various infections and is characterized by the development of cytopenias, hyperferritinemia, liver dysfunction, and coagulopa...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699014/ https://www.ncbi.nlm.nih.gov/pubmed/29279647 http://dx.doi.org/10.4103/0972-5229.218137 |
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author | Jayashree, K. Rao, Suchetha Kamath, Nutan |
author_facet | Jayashree, K. Rao, Suchetha Kamath, Nutan |
author_sort | Jayashree, K. |
collection | PubMed |
description | Macrophage activation syndrome (MAS) is a potentially fatal complication caused by excessive activation and expansion of macrophages and T lymphocytes. It can be triggered by various infections and is characterized by the development of cytopenias, hyperferritinemia, liver dysfunction, and coagulopathy. We report a 10-month-old female infant with fever, convulsions, and hepatosplenomegaly. Laboratory data of bicytopenia, low erythrocyte sedimentation rate, and elevated liver enzymes suggested MAS. This was supported by the presence of hyperferritinemia with hypertriglyceridemia. MAS was triggered by influenza B virus. She responded to treatment with immunoglobulin and steroid. |
format | Online Article Text |
id | pubmed-5699014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56990142017-12-26 Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant Jayashree, K. Rao, Suchetha Kamath, Nutan Indian J Crit Care Med Case Report Macrophage activation syndrome (MAS) is a potentially fatal complication caused by excessive activation and expansion of macrophages and T lymphocytes. It can be triggered by various infections and is characterized by the development of cytopenias, hyperferritinemia, liver dysfunction, and coagulopathy. We report a 10-month-old female infant with fever, convulsions, and hepatosplenomegaly. Laboratory data of bicytopenia, low erythrocyte sedimentation rate, and elevated liver enzymes suggested MAS. This was supported by the presence of hyperferritinemia with hypertriglyceridemia. MAS was triggered by influenza B virus. She responded to treatment with immunoglobulin and steroid. Medknow Publications & Media Pvt Ltd 2017-11 /pmc/articles/PMC5699014/ /pubmed/29279647 http://dx.doi.org/10.4103/0972-5229.218137 Text en Copyright: © 2017 Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Jayashree, K. Rao, Suchetha Kamath, Nutan Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant |
title | Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant |
title_full | Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant |
title_fullStr | Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant |
title_full_unstemmed | Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant |
title_short | Influenza B Virus Triggering Macrophage Activation Syndrome in an Infant |
title_sort | influenza b virus triggering macrophage activation syndrome in an infant |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699014/ https://www.ncbi.nlm.nih.gov/pubmed/29279647 http://dx.doi.org/10.4103/0972-5229.218137 |
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