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Mechanism of RNA polymerase II stalling by DNA alkylation

Several anticancer agents that form DNA adducts in the minor groove interfere with DNA replication and transcription to induce apoptosis. Therapeutic resistance can occur, however, when cells are proficient in the removal of drug-induced damage. Acylfulvenes are a class of experimental anticancer ag...

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Detalles Bibliográficos
Autores principales:	Malvezzi, Stefano, Farnung, Lucas, Aloisi, Claudia M. N., Angelov, Todor, Cramer, Patrick, Sturla, Shana J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2017
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699039/ https://www.ncbi.nlm.nih.gov/pubmed/29087308 http://dx.doi.org/10.1073/pnas.1706592114

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