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Sampling and energy evaluation challenges in ligand binding protein design

The steroid hormone 17α‐hydroxylprogesterone (17‐OHP) is a biomarker for congenital adrenal hyperplasia and hence there is considerable interest in development of sensors for this compound. We used computational protein design to generate protein models with binding sites for 17‐OHP containing an ex...

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Detalles Bibliográficos
Autores principales:	Dou, Jiayi, Doyle, Lindsey, Jr. Greisen, Per, Schena, Alberto, Park, Hahnbeom, Johnsson, Kai, Stoddard, Barry L., Baker, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699494/ https://www.ncbi.nlm.nih.gov/pubmed/28980354 http://dx.doi.org/10.1002/pro.3317

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