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Wobble uridine modifications–a reason to live, a reason to die?!

Wobble uridines (U(34)) are generally modified in all species. U(34) modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. W...

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Detalles Bibliográficos
Autores principales: Schaffrath, Raffael, Leidel, Sebastian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699542/
https://www.ncbi.nlm.nih.gov/pubmed/28277930
http://dx.doi.org/10.1080/15476286.2017.1295204
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author Schaffrath, Raffael
Leidel, Sebastian A.
author_facet Schaffrath, Raffael
Leidel, Sebastian A.
author_sort Schaffrath, Raffael
collection PubMed
description Wobble uridines (U(34)) are generally modified in all species. U(34) modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecular machinery required to introduce these modifications into tRNA posttranscriptionally and discuss how posttranslational regulation may affect the activity of the modifying enzymes. We highlight the activity of anticodon specific RNases that target U(34) containing tRNA. Finally, we discuss how defects in wobble uridine modifications lead to phenotypes in different species. Importantly, this review will mainly focus on the cytoplasmic tRNAs of eukaryotes. A recent review has extensively covered their bacterial and mitochondrial counterparts.(1)
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spelling pubmed-56995422017-12-01 Wobble uridine modifications–a reason to live, a reason to die?! Schaffrath, Raffael Leidel, Sebastian A. RNA Biol Review Wobble uridines (U(34)) are generally modified in all species. U(34) modifications can be essential in metazoans but are not required for viability in fungi. In this review, we provide an overview on the types of modifications and how they affect the physico-chemical properties of wobble uridines. We describe the molecular machinery required to introduce these modifications into tRNA posttranscriptionally and discuss how posttranslational regulation may affect the activity of the modifying enzymes. We highlight the activity of anticodon specific RNases that target U(34) containing tRNA. Finally, we discuss how defects in wobble uridine modifications lead to phenotypes in different species. Importantly, this review will mainly focus on the cytoplasmic tRNAs of eukaryotes. A recent review has extensively covered their bacterial and mitochondrial counterparts.(1) Taylor & Francis 2017-02-23 /pmc/articles/PMC5699542/ /pubmed/28277930 http://dx.doi.org/10.1080/15476286.2017.1295204 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Schaffrath, Raffael
Leidel, Sebastian A.
Wobble uridine modifications–a reason to live, a reason to die?!
title Wobble uridine modifications–a reason to live, a reason to die?!
title_full Wobble uridine modifications–a reason to live, a reason to die?!
title_fullStr Wobble uridine modifications–a reason to live, a reason to die?!
title_full_unstemmed Wobble uridine modifications–a reason to live, a reason to die?!
title_short Wobble uridine modifications–a reason to live, a reason to die?!
title_sort wobble uridine modifications–a reason to live, a reason to die?!
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699542/
https://www.ncbi.nlm.nih.gov/pubmed/28277930
http://dx.doi.org/10.1080/15476286.2017.1295204
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