A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players

RNA modifications are an emerging layer of posttranscriptional gene regulation in eukaryotes. N(6)-methyladenosine (m(6)A) is among the most abundant modifications in mRNAs (mRNAs) that was shown to influence many physiological processes from yeast to mammals. Like DNA methylation, m(6)A in mRNA is...

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Detalles Bibliográficos
Autores principales: Lence, Tina, Soller, Matthias, Roignant, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699544/
https://www.ncbi.nlm.nih.gov/pubmed/28353398
http://dx.doi.org/10.1080/15476286.2017.1307484
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author Lence, Tina
Soller, Matthias
Roignant, Jean-Yves
author_facet Lence, Tina
Soller, Matthias
Roignant, Jean-Yves
author_sort Lence, Tina
collection PubMed
description RNA modifications are an emerging layer of posttranscriptional gene regulation in eukaryotes. N(6)-methyladenosine (m(6)A) is among the most abundant modifications in mRNAs (mRNAs) that was shown to influence many physiological processes from yeast to mammals. Like DNA methylation, m(6)A in mRNA is dynamically regulated. A conserved methyltransferase complex catalyzes the deposition of the methyl group on adenosine, which can be removed by specific classes of demethylases. Furthermore, YTH-domain containing proteins can recognize this modification to mediate m(6)A-dependent activities. Here we review the functions and mechanisms of the main m(6)A players with a particular focus on Drosophila melanogaster.
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spelling pubmed-56995442017-12-01 A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players Lence, Tina Soller, Matthias Roignant, Jean-Yves RNA Biol Review RNA modifications are an emerging layer of posttranscriptional gene regulation in eukaryotes. N(6)-methyladenosine (m(6)A) is among the most abundant modifications in mRNAs (mRNAs) that was shown to influence many physiological processes from yeast to mammals. Like DNA methylation, m(6)A in mRNA is dynamically regulated. A conserved methyltransferase complex catalyzes the deposition of the methyl group on adenosine, which can be removed by specific classes of demethylases. Furthermore, YTH-domain containing proteins can recognize this modification to mediate m(6)A-dependent activities. Here we review the functions and mechanisms of the main m(6)A players with a particular focus on Drosophila melanogaster. Taylor & Francis 2017-03-29 /pmc/articles/PMC5699544/ /pubmed/28353398 http://dx.doi.org/10.1080/15476286.2017.1307484 Text en © 2017 IBM. Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Lence, Tina
Soller, Matthias
Roignant, Jean-Yves
A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players
title A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players
title_full A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players
title_fullStr A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players
title_full_unstemmed A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players
title_short A fly view on the roles and mechanisms of the m(6)A mRNA modification and its players
title_sort fly view on the roles and mechanisms of the m(6)a mrna modification and its players
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699544/
https://www.ncbi.nlm.nih.gov/pubmed/28353398
http://dx.doi.org/10.1080/15476286.2017.1307484
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