Observing the fate of tRNA and its modifications by nucleic acid isotope labeling mass spectrometry: NAIL-MS

RNA in yeast, especially rRNA and tRNA are heavily modified to fulfill their function in protein translation. Using biosynthetic stable isotope labeled internal standards we quantified 12 modified nucleosides in tRNA from S. cerevisiae over 24 hours. We observed different quantities of modified nucl...

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Detalles Bibliográficos
Autores principales: Heiss, Matthias, Reichle, Valentin F., Kellner, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699550/
https://www.ncbi.nlm.nih.gov/pubmed/28488916
http://dx.doi.org/10.1080/15476286.2017.1325063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699550/
https://www.ncbi.nlm.nih.gov/pubmed/28488916
http://dx.doi.org/10.1080/15476286.2017.1325063

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