An unfolded protein-induced conformational switch activates mammalian IRE1

The unfolded protein response (UPR) adjusts the cell’s protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells. It has remained controversial, however, whether mammalian and yeast IRE1 use a common mechanism for ER stres...

Descripción completa

Detalles Bibliográficos
Autores principales: Karagöz, G Elif, Acosta-Alvear, Diego, Nguyen, Hieu T, Lee, Crystal P, Chu, Feixia, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699868/
https://www.ncbi.nlm.nih.gov/pubmed/28971800
http://dx.doi.org/10.7554/eLife.30700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699868/
https://www.ncbi.nlm.nih.gov/pubmed/28971800
http://dx.doi.org/10.7554/eLife.30700

Ejemplares similares