Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis

Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized. We demonstrate that Mycobacterium tuberculosis...

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Detalles Bibliográficos
Autores principales: Brilha, Sara, Ong, Catherine W. M., Weksler, Babette, Romero, Nacho, Couraud, Pierre-Olivier, Friedland, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700087/
https://www.ncbi.nlm.nih.gov/pubmed/29167512
http://dx.doi.org/10.1038/s41598-017-16250-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700087/
https://www.ncbi.nlm.nih.gov/pubmed/29167512
http://dx.doi.org/10.1038/s41598-017-16250-3

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