Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus

Glucokinase is one of the promising targets for glucose-lowering agents, and the development of GK activators are now considered as one of the most promising strategies for the treatment of type 2 diabetes mellitus. In this work, a series of novel symmetric molecular constructs, in which two pyridox...

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Detalles Bibliográficos
Autores principales: Dzyurkevich, Mikhail S., Babkov, Denis A., Shtyrlin, Nikita V., Mayka, Olga Yu., Iksanova, Alfiya G., Vassiliev, Pavel M., Balakin, Konstantin V., Spasov, Alexander A., Tarasov, Vadim V., Barreto, George, Shtyrlin, Yurii G., Aliev, Gjumrakch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700121/
https://www.ncbi.nlm.nih.gov/pubmed/29167582
http://dx.doi.org/10.1038/s41598-017-16405-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700121/
https://www.ncbi.nlm.nih.gov/pubmed/29167582
http://dx.doi.org/10.1038/s41598-017-16405-2

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