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Radioligand binding analysis of α(2) adrenoceptors with [(11)C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding

We describe a novel method of kinetic analysis of radioligand binding to neuroreceptors in brain in vivo, here applied to noradrenaline receptors in rat brain. The method uses positron emission tomography (PET) of [(11)C]yohimbine binding in brain to quantify the density and affinity of α(2) adrenoc...

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Detalles Bibliográficos
Autores principales:	Phan, Jenny-Ann, Landau, Anne M., Jakobsen, Steen, Wong, Dean F., Gjedde, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700124/ https://www.ncbi.nlm.nih.gov/pubmed/29167492 http://dx.doi.org/10.1038/s41598-017-16020-1

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