Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversible inhibition of the immunoproteasome β5i subunit while sparing the constitutive β5c subuni...

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Detalles Bibliográficos
Autores principales: Santos, Ruda de Luna Almeida, Bai, Lin, Singh, Pradeep K., Murakami, Naoka, Fan, Hao, Zhan, Wenhu, Zhu, Yingrong, Jiang, Xiuju, Zhang, Kaiming, Assker, Jean Pierre, Nathan, Carl F., Li, Huilin, Azzi, Jamil, Lin, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700161/
https://www.ncbi.nlm.nih.gov/pubmed/29167449
http://dx.doi.org/10.1038/s41467-017-01760-5

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