Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis

We have identified the first case of an fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafung...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiménez-Ortigosa, Cristina, Moore, Caroline, Denning, David W., Perlin, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700295/
https://www.ncbi.nlm.nih.gov/pubmed/28923871
http://dx.doi.org/10.1128/AAC.01277-17
_version_ 1783281105628037120
author Jiménez-Ortigosa, Cristina
Moore, Caroline
Denning, David W.
Perlin, David S.
author_facet Jiménez-Ortigosa, Cristina
Moore, Caroline
Denning, David W.
Perlin, David S.
author_sort Jiménez-Ortigosa, Cristina
collection PubMed
description We have identified the first case of an fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafungin treatment.
format Online
Article
Text
id pubmed-5700295
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-57002952017-12-01 Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis Jiménez-Ortigosa, Cristina Moore, Caroline Denning, David W. Perlin, David S. Antimicrob Agents Chemother Mechanisms of Resistance We have identified the first case of an fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and polyene therapy and subsequently failed micafungin treatment. American Society for Microbiology 2017-11-22 /pmc/articles/PMC5700295/ /pubmed/28923871 http://dx.doi.org/10.1128/AAC.01277-17 Text en Copyright © 2017 Jiménez-Ortigosa et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Jiménez-Ortigosa, Cristina
Moore, Caroline
Denning, David W.
Perlin, David S.
Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis
title Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis
title_full Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis
title_fullStr Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis
title_full_unstemmed Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis
title_short Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis
title_sort emergence of echinocandin resistance due to a point mutation in the fks1 gene of aspergillus fumigatus in a patient with chronic pulmonary aspergillosis
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700295/
https://www.ncbi.nlm.nih.gov/pubmed/28923871
http://dx.doi.org/10.1128/AAC.01277-17
work_keys_str_mv AT jimenezortigosacristina emergenceofechinocandinresistanceduetoapointmutationinthefks1geneofaspergillusfumigatusinapatientwithchronicpulmonaryaspergillosis
AT moorecaroline emergenceofechinocandinresistanceduetoapointmutationinthefks1geneofaspergillusfumigatusinapatientwithchronicpulmonaryaspergillosis
AT denningdavidw emergenceofechinocandinresistanceduetoapointmutationinthefks1geneofaspergillusfumigatusinapatientwithchronicpulmonaryaspergillosis
AT perlindavids emergenceofechinocandinresistanceduetoapointmutationinthefks1geneofaspergillusfumigatusinapatientwithchronicpulmonaryaspergillosis

Ejemplares similares