Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance

Genetics-based drug susceptibility testing has improved the diagnosis of drug-resistant tuberculosis but is limited by our lack of knowledge of all resistance mechanisms. Next-generation sequencing has assisted in identifying the principal genetic mechanisms of resistance for many drugs, but a signi...

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Detalles Bibliográficos
Autores principales: de Welzen, Lynne, Eldholm, Vegard, Maharaj, Kashmeel, Manson, Abigail L., Earl, Ashlee M., Pym, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700317/
https://www.ncbi.nlm.nih.gov/pubmed/28993337
http://dx.doi.org/10.1128/AAC.01461-17

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