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Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma

PURPOSE: The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the d...

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Autores principales: Aydoğan, Tuğba, Akçay, Betül İlkay Sezgin, Kardeş, Esra, Ergin, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700582/
https://www.ncbi.nlm.nih.gov/pubmed/29133640
http://dx.doi.org/10.4103/ijo.IJO_157_17
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author Aydoğan, Tuğba
Akçay, Betül İlkay Sezgin
Kardeş, Esra
Ergin, Ahmet
author_facet Aydoğan, Tuğba
Akçay, Betül İlkay Sezgin
Kardeş, Esra
Ergin, Ahmet
author_sort Aydoğan, Tuğba
collection PubMed
description PURPOSE: The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of spectral domain-optical coherence tomography (SD-OCT) parameters and risk factors for glaucoma. METHODS: Three hundred and twenty-six eyes (89 healthy, 77 OHT, 94 PPG, and 66 EG eyes) were analyzed. RNFL, macular, and ONH parameters were measured with SD-OCT. The area under the receiver operating characteristic curve (AUC) and sensitivity at 95% specificity was calculated. Logistic regression analysis was used to determine the glaucoma risk factors. Receiver operating characteristic regression analysis was used to evaluate the influence of covariates on the diagnostic ability of parameters. RESULTS: In PPG patients, parameters that had the largest AUC value were average RNFL thickness (0.83) and rim volume (0.83). In EG patients, parameter that had the largest AUC value was average RNFL thickness (0.98). The logistic regression analysis showed average RNFL thickness was a risk factor for both PPG and EG. Diagnostic ability of average RNFL and average ganglion cell complex thickness increased as disease severity increased. Signal strength index did not affect diagnostic abilities. Diagnostic ability of average RNFL and rim area increased as disc area increased. CONCLUSION: When evaluating patients with glaucoma, patients at risk for glaucoma, and healthy controls RNFL parameters deserve more attention in clinical practice. Further studies are needed to fully understand the influence of covariates on the diagnostic ability of OCT parameters.
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spelling pubmed-57005822017-12-01 Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma Aydoğan, Tuğba Akçay, Betül İlkay Sezgin Kardeş, Esra Ergin, Ahmet Indian J Ophthalmol Original Article PURPOSE: The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of spectral domain-optical coherence tomography (SD-OCT) parameters and risk factors for glaucoma. METHODS: Three hundred and twenty-six eyes (89 healthy, 77 OHT, 94 PPG, and 66 EG eyes) were analyzed. RNFL, macular, and ONH parameters were measured with SD-OCT. The area under the receiver operating characteristic curve (AUC) and sensitivity at 95% specificity was calculated. Logistic regression analysis was used to determine the glaucoma risk factors. Receiver operating characteristic regression analysis was used to evaluate the influence of covariates on the diagnostic ability of parameters. RESULTS: In PPG patients, parameters that had the largest AUC value were average RNFL thickness (0.83) and rim volume (0.83). In EG patients, parameter that had the largest AUC value was average RNFL thickness (0.98). The logistic regression analysis showed average RNFL thickness was a risk factor for both PPG and EG. Diagnostic ability of average RNFL and average ganglion cell complex thickness increased as disease severity increased. Signal strength index did not affect diagnostic abilities. Diagnostic ability of average RNFL and rim area increased as disc area increased. CONCLUSION: When evaluating patients with glaucoma, patients at risk for glaucoma, and healthy controls RNFL parameters deserve more attention in clinical practice. Further studies are needed to fully understand the influence of covariates on the diagnostic ability of OCT parameters. Medknow Publications & Media Pvt Ltd 2017-11 /pmc/articles/PMC5700582/ /pubmed/29133640 http://dx.doi.org/10.4103/ijo.IJO_157_17 Text en Copyright: © 2017 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Aydoğan, Tuğba
Akçay, Betül İlkay Sezgin
Kardeş, Esra
Ergin, Ahmet
Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma
title Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma
title_full Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma
title_fullStr Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma
title_full_unstemmed Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma
title_short Evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma
title_sort evaluation of spectral domain optical coherence tomography parameters in ocular hypertension, preperimetric, and early glaucoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700582/
https://www.ncbi.nlm.nih.gov/pubmed/29133640
http://dx.doi.org/10.4103/ijo.IJO_157_17
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