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Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits
BACKGROUND: Cognitive deficits are a core feature of early schizophrenia. However, the pathological foundations underlying cognitive deficits are still unknown. The present study examined the association between gray matter density and cognitive deficits in first-episode schizophrenia. METHOD: Struc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700743/ https://www.ncbi.nlm.nih.gov/pubmed/29166884 http://dx.doi.org/10.1186/s12888-017-1543-4 |
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author | Wang, Jingjuan Zhou, Li Cui, Chunlei Liu, Zhening Lu, Jie |
author_facet | Wang, Jingjuan Zhou, Li Cui, Chunlei Liu, Zhening Lu, Jie |
author_sort | Wang, Jingjuan |
collection | PubMed |
description | BACKGROUND: Cognitive deficits are a core feature of early schizophrenia. However, the pathological foundations underlying cognitive deficits are still unknown. The present study examined the association between gray matter density and cognitive deficits in first-episode schizophrenia. METHOD: Structural magnetic resonance imaging of the brain was performed in 34 first-episode schizophrenia patients and 21 healthy controls. Patients were divided into two subgroups according to working memory task performance. The three groups were well matched for age, gender, and education, and the two patient groups were also further matched for diagnosis, duration of illness, and antipsychotic treatment. Voxel-based morphometric analysis was performed to estimate changes in gray matter density in first-episode schizophrenia patients with cognitive deficits. The relationships between gray matter density and clinical outcomes were explored. RESULTS: Patients with cognitive deficits were found to have reduced gray matter density in the vermis and tonsil of cerebellum compared with patients without cognitive deficits and healthy controls, decreased gray matter density in left supplementary motor area, bilateral precentral gyrus compared with patients without cognitive deficits. Classifier results showed GMD in cerebellar vermis tonsil cluster could differentiate SZ-CD from controls, left supplementary motor area cluster could differentiate SZ-CD from SZ-NCD. Gray matter density values of the cerebellar vermis cluster in patients groups were positively correlated with cognitive severity. CONCLUSIONS: Decreased gray matter density in the vermis and tonsil of cerebellum may underlie early psychosis and serve as a candidate biomarker for schizophrenia with cognitive deficits. |
format | Online Article Text |
id | pubmed-5700743 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57007432017-12-01 Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits Wang, Jingjuan Zhou, Li Cui, Chunlei Liu, Zhening Lu, Jie BMC Psychiatry Research Article BACKGROUND: Cognitive deficits are a core feature of early schizophrenia. However, the pathological foundations underlying cognitive deficits are still unknown. The present study examined the association between gray matter density and cognitive deficits in first-episode schizophrenia. METHOD: Structural magnetic resonance imaging of the brain was performed in 34 first-episode schizophrenia patients and 21 healthy controls. Patients were divided into two subgroups according to working memory task performance. The three groups were well matched for age, gender, and education, and the two patient groups were also further matched for diagnosis, duration of illness, and antipsychotic treatment. Voxel-based morphometric analysis was performed to estimate changes in gray matter density in first-episode schizophrenia patients with cognitive deficits. The relationships between gray matter density and clinical outcomes were explored. RESULTS: Patients with cognitive deficits were found to have reduced gray matter density in the vermis and tonsil of cerebellum compared with patients without cognitive deficits and healthy controls, decreased gray matter density in left supplementary motor area, bilateral precentral gyrus compared with patients without cognitive deficits. Classifier results showed GMD in cerebellar vermis tonsil cluster could differentiate SZ-CD from controls, left supplementary motor area cluster could differentiate SZ-CD from SZ-NCD. Gray matter density values of the cerebellar vermis cluster in patients groups were positively correlated with cognitive severity. CONCLUSIONS: Decreased gray matter density in the vermis and tonsil of cerebellum may underlie early psychosis and serve as a candidate biomarker for schizophrenia with cognitive deficits. BioMed Central 2017-11-22 /pmc/articles/PMC5700743/ /pubmed/29166884 http://dx.doi.org/10.1186/s12888-017-1543-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Wang, Jingjuan Zhou, Li Cui, Chunlei Liu, Zhening Lu, Jie Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits |
title | Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits |
title_full | Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits |
title_fullStr | Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits |
title_full_unstemmed | Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits |
title_short | Gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits |
title_sort | gray matter morphological anomalies in the cerebellar vermis in first-episode schizophrenia patients with cognitive deficits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700743/ https://www.ncbi.nlm.nih.gov/pubmed/29166884 http://dx.doi.org/10.1186/s12888-017-1543-4 |
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