Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease

Alcohol metabolism in the liver generates highly toxic acetaldehyde. Breakdown of acetaldehyde by aldehyde dehydrogenase 2 (ALDH2) in the mitochondria consumes NAD(+) and generates reactive oxygen/nitrogen species, which represents a fundamental mechanism in the pathogenesis of alcoholic liver disea...

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Detalles Bibliográficos
Autores principales: Hao, Liuyi, Sun, Qian, Zhong, Wei, Zhang, Wenliang, Sun, Xinguo, Zhou, Zhanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700831/
https://www.ncbi.nlm.nih.gov/pubmed/29156373
http://dx.doi.org/10.1016/j.redox.2017.11.005

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