New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review

Although current therapies can be successful at suppressing hepatitis B viral load, long-term viral cure is not within reach. Subsequent strategies combining pegylated interferon alfa with nucleoside/nucleotide analogues have not resulted in any major paradigm shift. An improved understanding of the...

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Autores principales: Arends, Joop E., Lieveld, Faydra I., Ahmad, Shazaad, Ustianowski, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700893/
https://www.ncbi.nlm.nih.gov/pubmed/29071665
http://dx.doi.org/10.1007/s40121-017-0173-y
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author Arends, Joop E.
Lieveld, Faydra I.
Ahmad, Shazaad
Ustianowski, Andrew
author_facet Arends, Joop E.
Lieveld, Faydra I.
Ahmad, Shazaad
Ustianowski, Andrew
author_sort Arends, Joop E.
collection PubMed
description Although current therapies can be successful at suppressing hepatitis B viral load, long-term viral cure is not within reach. Subsequent strategies combining pegylated interferon alfa with nucleoside/nucleotide analogues have not resulted in any major paradigm shift. An improved understanding of the hepatitis B virus (HBV) lifec ycle and virus-induced immune dysregulation has, however, revealed many potential therapeutic targets, and there are hopes that treatment of hepatitis B could soon be revolutionized. This review summarizes the current developments in HBV therapeutics—both virus directed and host directed.
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spelling pubmed-57008932017-12-05 New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review Arends, Joop E. Lieveld, Faydra I. Ahmad, Shazaad Ustianowski, Andrew Infect Dis Ther Review Although current therapies can be successful at suppressing hepatitis B viral load, long-term viral cure is not within reach. Subsequent strategies combining pegylated interferon alfa with nucleoside/nucleotide analogues have not resulted in any major paradigm shift. An improved understanding of the hepatitis B virus (HBV) lifec ycle and virus-induced immune dysregulation has, however, revealed many potential therapeutic targets, and there are hopes that treatment of hepatitis B could soon be revolutionized. This review summarizes the current developments in HBV therapeutics—both virus directed and host directed. Springer Healthcare 2017-10-25 2017-12 /pmc/articles/PMC5700893/ /pubmed/29071665 http://dx.doi.org/10.1007/s40121-017-0173-y Text en © The Author(s) 2017 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Arends, Joop E.
Lieveld, Faydra I.
Ahmad, Shazaad
Ustianowski, Andrew
New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review
title New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review
title_full New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review
title_fullStr New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review
title_full_unstemmed New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review
title_short New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review
title_sort new viral and immunological targets for hepatitis b treatment and cure: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700893/
https://www.ncbi.nlm.nih.gov/pubmed/29071665
http://dx.doi.org/10.1007/s40121-017-0173-y
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