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Anisotropic dehydration of hydrogel surfaces

Efforts to develop tissue-engineered skin for regenerative medicine have explored natural, synthetic, and hybrid hydrogels. The creation of a bilayer material, with the stratification exhibited by native skin, is a complex problem. The mechanically robust, waterproof epidermis presents the stratum c...

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Autores principales: Kaklamani, Georgia, Cheneler, David, Grover, Liam M., Adams, Michael J., Anastasiadis, Spiros H., Bowen, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700910/
https://www.ncbi.nlm.nih.gov/pubmed/29063422
http://dx.doi.org/10.1007/s40204-017-0075-9
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author Kaklamani, Georgia
Cheneler, David
Grover, Liam M.
Adams, Michael J.
Anastasiadis, Spiros H.
Bowen, James
author_facet Kaklamani, Georgia
Cheneler, David
Grover, Liam M.
Adams, Michael J.
Anastasiadis, Spiros H.
Bowen, James
author_sort Kaklamani, Georgia
collection PubMed
description Efforts to develop tissue-engineered skin for regenerative medicine have explored natural, synthetic, and hybrid hydrogels. The creation of a bilayer material, with the stratification exhibited by native skin, is a complex problem. The mechanically robust, waterproof epidermis presents the stratum corneum at the tissue/air interface, which confers many of these protective properties. In this work, we explore the effect of high temperatures on alginate hydrogels, which are widely employed for tissue engineering due to their excellent mechanical properties and cellular compatibility. In particular, we investigate the rapid dehydration of the hydrogel surface which occurs following local exposure to heated surfaces with temperatures in the range 100–200 °C. We report the creation of a mechanically strengthened hydrogel surface, with improved puncture resistance and increased coefficient of friction, compared to an unheated surface. The use of a mechanical restraint during heating promoted differences in the rate of mass loss; the rate of temperature increase within the hydrogel, in the presence and absence of restraint, is simulated and discussed. It is hoped that the results will be of use in the development of processes suitable for preparing skin-like analogues; application areas could include wound healing and skin restoration.
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spelling pubmed-57009102017-12-04 Anisotropic dehydration of hydrogel surfaces Kaklamani, Georgia Cheneler, David Grover, Liam M. Adams, Michael J. Anastasiadis, Spiros H. Bowen, James Prog Biomater Original Research Efforts to develop tissue-engineered skin for regenerative medicine have explored natural, synthetic, and hybrid hydrogels. The creation of a bilayer material, with the stratification exhibited by native skin, is a complex problem. The mechanically robust, waterproof epidermis presents the stratum corneum at the tissue/air interface, which confers many of these protective properties. In this work, we explore the effect of high temperatures on alginate hydrogels, which are widely employed for tissue engineering due to their excellent mechanical properties and cellular compatibility. In particular, we investigate the rapid dehydration of the hydrogel surface which occurs following local exposure to heated surfaces with temperatures in the range 100–200 °C. We report the creation of a mechanically strengthened hydrogel surface, with improved puncture resistance and increased coefficient of friction, compared to an unheated surface. The use of a mechanical restraint during heating promoted differences in the rate of mass loss; the rate of temperature increase within the hydrogel, in the presence and absence of restraint, is simulated and discussed. It is hoped that the results will be of use in the development of processes suitable for preparing skin-like analogues; application areas could include wound healing and skin restoration. Springer Berlin Heidelberg 2017-10-23 /pmc/articles/PMC5700910/ /pubmed/29063422 http://dx.doi.org/10.1007/s40204-017-0075-9 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Kaklamani, Georgia
Cheneler, David
Grover, Liam M.
Adams, Michael J.
Anastasiadis, Spiros H.
Bowen, James
Anisotropic dehydration of hydrogel surfaces
title Anisotropic dehydration of hydrogel surfaces
title_full Anisotropic dehydration of hydrogel surfaces
title_fullStr Anisotropic dehydration of hydrogel surfaces
title_full_unstemmed Anisotropic dehydration of hydrogel surfaces
title_short Anisotropic dehydration of hydrogel surfaces
title_sort anisotropic dehydration of hydrogel surfaces
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700910/
https://www.ncbi.nlm.nih.gov/pubmed/29063422
http://dx.doi.org/10.1007/s40204-017-0075-9
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