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Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

MicroRNAs regulate the expression of many proteins and require specific maturation steps. Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing the RNase Drosha and its partner protein, DGCR8. Although DGCR8 is known to bind heme, the molecular role of heme in p...

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Detalles Bibliográficos
Autores principales:	Partin, Alexander C., Ngo, Tri D., Herrell, Emily, Jeong, Byung-Cheon, Hon, Gary, Nam, Yunsun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700927/ https://www.ncbi.nlm.nih.gov/pubmed/29170488 http://dx.doi.org/10.1038/s41467-017-01713-y

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