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Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

The target of rapamycin (TOR) kinase assembles into two distinct multiprotein complexes, conserved across eukaryote evolution. In contrast to TOR complex 1 (TORC1), TORC2 kinase activity is not inhibited by the macrolide rapamycin. Here, we present the structure of Saccharomyces cerevisiae TORC2 det...

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Detalles Bibliográficos
Autores principales:	Karuppasamy, Manikandan, Kusmider, Beata, Oliveira, Taiana M., Gaubitz, Christl, Prouteau, Manoel, Loewith, Robbie, Schaffitzel, Christiane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700991/ https://www.ncbi.nlm.nih.gov/pubmed/29170376 http://dx.doi.org/10.1038/s41467-017-01862-0

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