Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

Activation of transmembrane receptor integrin by talin is essential for inducing cell adhesion. However, the pathway that recruits talin to the membrane, which critically controls talin’s action, remains elusive. Membrane-anchored mammalian small GTPase Rap1 is known to bind talin-F0 domain but the...

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Detalles Bibliográficos
Autores principales: Zhu, Liang, Yang, Jun, Bromberger, Thomas, Holly, Ashley, Lu, Fan, Liu, Huan, Sun, Kevin, Klapproth, Sarah, Hirbawi, Jamila, Byzova, Tatiana V., Plow, Edward F., Moser, Markus, Qin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701058/
https://www.ncbi.nlm.nih.gov/pubmed/29170462
http://dx.doi.org/10.1038/s41467-017-01822-8

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