Roles of PFKFB3 in cancer

The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in human macrophages in the mid-1990s. As a vital regulator of glycolysis, accumulating studies have suggested that PFKFB3 is associated with...

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Detalles Bibliográficos
Autores principales: Shi, Linlin, Pan, Hongming, Liu, Zhen, Xie, Jiansheng, Han, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701083/
https://www.ncbi.nlm.nih.gov/pubmed/29263928
http://dx.doi.org/10.1038/sigtrans.2017.44
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author Shi, Linlin
Pan, Hongming
Liu, Zhen
Xie, Jiansheng
Han, Weidong
author_facet Shi, Linlin
Pan, Hongming
Liu, Zhen
Xie, Jiansheng
Han, Weidong
author_sort Shi, Linlin
collection PubMed
description The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in human macrophages in the mid-1990s. As a vital regulator of glycolysis, accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer, including carcinogenesis, cancer cell proliferation, vessel aggressiveness, drug resistance and tumor microenvironment. In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues. Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy.
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spelling pubmed-57010832017-12-20 Roles of PFKFB3 in cancer Shi, Linlin Pan, Hongming Liu, Zhen Xie, Jiansheng Han, Weidong Signal Transduct Target Ther Review Article The understanding of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFK-2/FBPase 3, PFKFB3) has advanced considerably since its initial identification in human macrophages in the mid-1990s. As a vital regulator of glycolysis, accumulating studies have suggested that PFKFB3 is associated with many aspects of cancer, including carcinogenesis, cancer cell proliferation, vessel aggressiveness, drug resistance and tumor microenvironment. In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer tissues. Ubiquitous PFKFB3 has emerged as a potential target for anti-neoplastic therapy. Nature Publishing Group 2017-11-24 /pmc/articles/PMC5701083/ /pubmed/29263928 http://dx.doi.org/10.1038/sigtrans.2017.44 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review Article
Shi, Linlin
Pan, Hongming
Liu, Zhen
Xie, Jiansheng
Han, Weidong
Roles of PFKFB3 in cancer
title Roles of PFKFB3 in cancer
title_full Roles of PFKFB3 in cancer
title_fullStr Roles of PFKFB3 in cancer
title_full_unstemmed Roles of PFKFB3 in cancer
title_short Roles of PFKFB3 in cancer
title_sort roles of pfkfb3 in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701083/
https://www.ncbi.nlm.nih.gov/pubmed/29263928
http://dx.doi.org/10.1038/sigtrans.2017.44
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AT hanweidong rolesofpfkfb3incancer

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