Cargando…
Safety and Feasibility Study of a Novel Stent-Graft for Thoracic Endovascular Aortic Repair: a Canine Model Experiment
OBJECTIVE: To evaluate the safety and feasibility of a novel stent-graft for thoracic endovascular aortic repair (TEVAR) in a canine model, 9 adult hybrid dogs were used for the experiment. METHODS: All animals were implanted with a novel thoracic aortic stent-graft via femoral artery. Blood sample...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cirurgia Cardiovascular
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701097/ https://www.ncbi.nlm.nih.gov/pubmed/29211221 http://dx.doi.org/10.21470/1678-9741-2016-0058 |
_version_ | 1783281265052483584 |
---|---|
author | Yang, Fan Qiu, Jiehua Fu, Zeliang Qiu, Yuchen Luo, Junrong Xiao, Qingyang Cao, Huabin |
author_facet | Yang, Fan Qiu, Jiehua Fu, Zeliang Qiu, Yuchen Luo, Junrong Xiao, Qingyang Cao, Huabin |
author_sort | Yang, Fan |
collection | PubMed |
description | OBJECTIVE: To evaluate the safety and feasibility of a novel stent-graft for thoracic endovascular aortic repair (TEVAR) in a canine model, 9 adult hybrid dogs were used for the experiment. METHODS: All animals were implanted with a novel thoracic aortic stent-graft via femoral artery. Blood sample was collected at pre-operation and 1, 2, 4, 8 and 12 weeks after implantation for hematological examination. Moreover, tissues from randomly selected 4 dogs were subjected to histopathological analysis with the optical microscope after stent-grafts were implanted for 3, 6, 9, and 12 months respectively. The experimental period lasted for more than 2 years. RESULTS: A total of 9 stent-grafts were successfully implanted in the canine thoracic aortas and no migration or deformation occurred. Related indicators of blood routine, inflammatory factors, and immunology changes were not significantly (P>0.05), except the white blood cell (WBC) counts in the first week. Moreover, abnormal morphology was not found in all thoracic aortas via histopathological examination. Additionally, all stent-grafts were patent and did not migrate, and there was no thrombus in the lumens of stent-grafts. CONCLUSION: The novel thoracic aortic stent-graft made in China was safe and feasible for thoracic endovascular aortic repair in a canine model. |
format | Online Article Text |
id | pubmed-5701097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
record_format | MEDLINE/PubMed |
spelling | pubmed-57010972017-11-28 Safety and Feasibility Study of a Novel Stent-Graft for Thoracic Endovascular Aortic Repair: a Canine Model Experiment Yang, Fan Qiu, Jiehua Fu, Zeliang Qiu, Yuchen Luo, Junrong Xiao, Qingyang Cao, Huabin Braz J Cardiovasc Surg Original Article OBJECTIVE: To evaluate the safety and feasibility of a novel stent-graft for thoracic endovascular aortic repair (TEVAR) in a canine model, 9 adult hybrid dogs were used for the experiment. METHODS: All animals were implanted with a novel thoracic aortic stent-graft via femoral artery. Blood sample was collected at pre-operation and 1, 2, 4, 8 and 12 weeks after implantation for hematological examination. Moreover, tissues from randomly selected 4 dogs were subjected to histopathological analysis with the optical microscope after stent-grafts were implanted for 3, 6, 9, and 12 months respectively. The experimental period lasted for more than 2 years. RESULTS: A total of 9 stent-grafts were successfully implanted in the canine thoracic aortas and no migration or deformation occurred. Related indicators of blood routine, inflammatory factors, and immunology changes were not significantly (P>0.05), except the white blood cell (WBC) counts in the first week. Moreover, abnormal morphology was not found in all thoracic aortas via histopathological examination. Additionally, all stent-grafts were patent and did not migrate, and there was no thrombus in the lumens of stent-grafts. CONCLUSION: The novel thoracic aortic stent-graft made in China was safe and feasible for thoracic endovascular aortic repair in a canine model. Sociedade Brasileira de Cirurgia Cardiovascular 2017 /pmc/articles/PMC5701097/ /pubmed/29211221 http://dx.doi.org/10.21470/1678-9741-2016-0058 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yang, Fan Qiu, Jiehua Fu, Zeliang Qiu, Yuchen Luo, Junrong Xiao, Qingyang Cao, Huabin Safety and Feasibility Study of a Novel Stent-Graft for Thoracic Endovascular Aortic Repair: a Canine Model Experiment |
title | Safety and Feasibility Study of a Novel Stent-Graft for Thoracic
Endovascular Aortic Repair: a Canine Model Experiment |
title_full | Safety and Feasibility Study of a Novel Stent-Graft for Thoracic
Endovascular Aortic Repair: a Canine Model Experiment |
title_fullStr | Safety and Feasibility Study of a Novel Stent-Graft for Thoracic
Endovascular Aortic Repair: a Canine Model Experiment |
title_full_unstemmed | Safety and Feasibility Study of a Novel Stent-Graft for Thoracic
Endovascular Aortic Repair: a Canine Model Experiment |
title_short | Safety and Feasibility Study of a Novel Stent-Graft for Thoracic
Endovascular Aortic Repair: a Canine Model Experiment |
title_sort | safety and feasibility study of a novel stent-graft for thoracic
endovascular aortic repair: a canine model experiment |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701097/ https://www.ncbi.nlm.nih.gov/pubmed/29211221 http://dx.doi.org/10.21470/1678-9741-2016-0058 |
work_keys_str_mv | AT yangfan safetyandfeasibilitystudyofanovelstentgraftforthoracicendovascularaorticrepairacaninemodelexperiment AT qiujiehua safetyandfeasibilitystudyofanovelstentgraftforthoracicendovascularaorticrepairacaninemodelexperiment AT fuzeliang safetyandfeasibilitystudyofanovelstentgraftforthoracicendovascularaorticrepairacaninemodelexperiment AT qiuyuchen safetyandfeasibilitystudyofanovelstentgraftforthoracicendovascularaorticrepairacaninemodelexperiment AT luojunrong safetyandfeasibilitystudyofanovelstentgraftforthoracicendovascularaorticrepairacaninemodelexperiment AT xiaoqingyang safetyandfeasibilitystudyofanovelstentgraftforthoracicendovascularaorticrepairacaninemodelexperiment AT caohuabin safetyandfeasibilitystudyofanovelstentgraftforthoracicendovascularaorticrepairacaninemodelexperiment |